Evidence map›Paper›PMID 35430253›Full record

ArticleThe Journal of biological chemistry2022

Evolution of Streptococcus pyogenes has maximized the efficiency of the Sortase A cleavage motif for cell wall transpeptidation.

Bradley M Readnour, Yetunde A Ayinuola, Brady T Russo, Zhong Liang, Shaun W Lee, Victoria A Ploplis, Vincent A Fischetti, Francis J Castellino

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Bradley M ReadnourW. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, Indiana, USA; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.
Yetunde A AyinuolaW. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, Indiana, USA.
Brady T RussoW. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, Indiana, USA; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.
Zhong LiangW. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, Indiana, USA.
Shaun W LeeW. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, Indiana, USA; Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA.
Victoria A PloplisW. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, Indiana, USA; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.
Vincent A FischettiLaboratory of Bacterial Pathogenesis and Immunology, Rockefeller University, New York, New York, USA.
Francis J CastellinoW. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, Indiana, USA; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA. Electronic address: fcastell@nd.edu.
University of Notre Dame · USRockefeller University · US

Funding

STRUCTURE-FUNCTION STUDIES ON PLASMINOGEN AND PLASMINR01HL013423 · NHLBI · UNIVERSITY OF NOTRE DAME · PI CASTELLINO, FRANCIS J, LEE, SHAUN · 1985 to 2021
$7.9M
Plasminogen and Plasmin: Structure and FunctionR56HL013423 · NHLBI · UNIVERSITY OF NOTRE DAME · PI CASTELLINO, FRANCIS J, LEE, SHAUN · 2022 to 2022
$743k
STRUCTURE/FUNCTION STUDIES ON PLASMINOGEN AND PLASMINR37HL013423 · NHLBI · UNIVERSITY OF NOTRE DAME · PI CASTELLINO, FRANCIS J · 1990 to 1999
–
NHLBI NIH HHS R01 HL013423NHLBI NIH HHS R37 HL013423NHLBI NIH HHS R56 HL013423
6 · The paper itself

Abstract

Trafficking of M-protein (Mprt) from the cytosol of Group A Streptococcus pyogenes (GAS) occurs via Sec translocase membrane channels that associate with Sortase A (SrtA), an enzyme that catalyzes cleavage of Mprt at the proximal C-terminal [-LPST

Indexed as

AminoacyltransferasesBacterial ProteinsCell WallStreptococcus pyogenesBiological EvolutionCysteine EndopeptidasesMutationAminoacyltransferasesBacterial ProteinsCysteine Endopeptidasessortase Abacteriabacterial pathogenesisc2ll membrane enzymescell surfacecell wallligand-binding proteinmutagenesisplasminogenStreptococcus pyogenessubcellular fractionation

Identifiers

PMID35430253
PMCPMC9123276
OpenAlexW4224102590

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.