Observational studyThe Journal of pediatrics2022
Neonatal Intensive Care Unit Network Neurobehavioral Scale Profiles in Full-Term Infants: Associations with Maternal Adversity, Medical Risk, and Neonatal Outcomes.
Observational study in The Journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Maternal neighborhood deprivation and its association with early childhood neurodevelopmental impairment in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Associations between maternal emotion dysregulation, infant negative affect and toddler mental health depend on newborn neurobehavioral profiles.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Study Protocol for a Randomized Controlled Trial of Multisensory Early Oral Administration of Human Milk (M-MILK) for Very Preterm Infants: Enhancing Stress Regulation, Neurodevelopment, and Oral Feeding Skills.Biological research for nursing · 2026Article
- Neurobehavioral Profiles in Low-Risk Infants: Associations With Prenatal Maternal Biobehavior and Birth Characteristics.Developmental psychobiology · 2025Article
- Extending the Branches of Neonatal Neurocritical Care.Seminars in perinatology · 2025Review
- Neurobehavioral Profiles in Opioid-Exposed and Unexposed Neonates.The Journal of pediatrics · 2025Observational
- Neurobehavioral outcomes of preterm infants: toward a holistic approach.Pediatric research · 2025Review
- Abnormal neurobehavior profiles observed in the newborn period following low-to-moderate prenatal alcohol exposure.Alcohol, clinical & experimental research · 2025Article
- Prevalence and characteristics of infants' prosocial helping strategies between 11 and 20 months of age.Developmental psychology · 2025Article
- The Irritable Infant in the Neonatal Intensive Care Unit: Risk Factors and Biomarkers of Gastroesophageal Reflux Disease.The Journal of pediatrics · 2024Article
- Prenatal and perinatal factors associated with neonatal neurobehavioral profiles in the ECHO Program.Pediatric research · 2023Article
- Neighborhood Deprivation and Association With Neonatal Intensive Care Unit Mortality and Morbidity for Extremely Premature Infants.JAMA network open · 2023Article
- Analysis of Neonatal Neurobehavior and Developmental Outcomes Among Preterm Infants.JAMA network open · 2022Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo examine healthy, full-term neonatal behavior using the Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS) in relation to measures of maternal adversity, maternal medical risk, and infant brain volumes. STUDY
designThis was a prospective, longitudinal, observational cohort study of pregnant mothers followed from the first trimester and their healthy, full-term infants. Infants underwent an NNNS assessment and high-quality magnetic resonance imaging 2-5 weeks after birth. A latent profile analysis of NNNS scores categorized infants into neurobehavioral profiles. Univariate and multivariate analyses compared differences in maternal factors (social advantage, psychosocial stress, and medical risk) and neonatal characteristics between profiles.
resultsThe latent profile analysis of NNNS summary scales of 296 infants generated 3 profiles: regulated (46.6%), hypotonic (16.6%), and fussy (36.8%). Infants with a hypotonic profile were more likely to be male (χ
conclusionsThree distinct neurobehavioral profiles were identified in healthy, full-term infants with hypotonic and fussy neurobehavioral features related to neonatal brain volumes and head circumference, but not prenatal exposure to socioeconomic or psychosocial adversity. Follow-up beyond the neonatal period will determine if identified profiles at birth are associated with subsequent clinical or developmental outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.