Evidence map›Paper›PMID 35430064›Full record

ArticlePesticide biochemistry and physiology2022

Pyrethroid resistance in the New World malaria vector Anopheles albimanus is mediated by cytochrome P450 CYP6P5.

Michael O Kusimo, Lucy Mackenzie-Impoinvil, Sulaiman S Ibrahim, Abdullahi Muhammad, Helen Irving, Jack Hearn, Audrey E Lenhart, Charles S Wondji

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pesticide biochemistry and physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Distinct Genetic Footprint of Adaptation Observed WithinResearch and reports in tropical medicine · 2026
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  6. Functional Validation of Endogenous Redox PartnerInternational journal of molecular sciences · 2024
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 4 countries.

Michael O KusimoLSTM Research Unit, Centre for Research in Infectious Diseases (CRID), P.O. Box 13591, Yaoundé, Cameroon. Electronic address: michael.kusimo@crid-cam.net.
Lucy Mackenzie-ImpoinvilEntomology Branch, Division of Parasitic Diseases and Malaria, Centre for Global Health, Centres for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30329, USA.
Sulaiman S IbrahimVector Biology Department, Liverpool School of Tropical Medicine (LSTM), Liverpool L3 5QA, UK; Department of Biochemistry, Bayero University, PMB 3011 Kano, Nigeria. Electronic address: suleiman.ibrahim@lstmed.ac.uk.
Abdullahi MuhammadVector Biology Department, Liverpool School of Tropical Medicine (LSTM), Liverpool L3 5QA, UK; Centre for Biotechnology Research, Bayero University, PMB 3011 Kano, Nigeria.
Helen IrvingVector Biology Department, Liverpool School of Tropical Medicine (LSTM), Liverpool L3 5QA, UK.
Jack HearnVector Biology Department, Liverpool School of Tropical Medicine (LSTM), Liverpool L3 5QA, UK.
Audrey E LenhartEntomology Branch, Division of Parasitic Diseases and Malaria, Centre for Global Health, Centres for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30329, USA.
Charles S WondjiLSTM Research Unit, Centre for Research in Infectious Diseases (CRID), P.O. Box 13591, Yaoundé, Cameroon; Vector Biology Department, Liverpool School of Tropical Medicine (LSTM), Liverpool L3 5QA, UK.
Liverpool School of Tropical Medicine · GBDivision of Parasitic Diseases and Malaria · USMinistry of Scientific Research and Innovation · CM

Funding

Wellcome Trust 201918/Z/16/Z
6 · The paper itself

Abstract

Pyrethroid resistance in the malaria vector Anopheles albimanus presents an obstacle to malaria elimination in the Americas. Here, An. albimanus CYP6P5 (the most overexpressed P450 in a Peruvian population) was functionally characterized. Recombinant CYP6P5 metabolized the type II pyrethroids, deltamethrin and α-cypermethrin with comparable affinities (K

Indexed as

AnophelesInsecticidesMalariaPyrethrinsAnimalsCytochrome P-450 Enzyme SystemDrosophila melanogasterInsecticide ResistanceMosquito ControlMosquito VectorsCytochrome P-450 Enzyme SystemInsecticidesPyrethrinsAnopheles albimanusCYP6P5MetabolicResistanceα-Cypermethrin

Identifiers

PMID35430064
PMCPMC9125164
OpenAlexW4214541048

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.