ArticleBMC cardiovascular disorders2022
Wellens' syndrome: incidence, characteristics, and long-term clinical outcomes.
Article in BMC cardiovascular disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Correction to "Characteristics of Wellens' Syndrome in the Current PCI Era: A Single-Center Retrospective Study".Emergency medicine international · 2026Article
- Wellens Syndrome Corollaries: A Call for Definition with a Case Series.Clinical practice and cases in emergency medicine · 2025Article
- Troponin May Lie: Recognizing an Atypical Case of Wellens Syndrome.Clinical case reports · 2025Article
- Advances in the study of Wellens syndrome.The Journal of international medical research · 2025Review
- Uncommon association of coronary artery ectasia and myocardial bridge presenting as non-ST-segment elevation myocardial infarction: a case report.Frontiers in cardiovascular medicine · 2025Article
- Wellen's syndrome caused by severe ostial stenosis of the left main coronary artery: a case report.BMC cardiovascular disorders · 2024Article
- From Wellens' syndrome to acute anterior myocardial infarction, what is required? Only time!The Journal of international medical research · 2024Article
- Article
- Wellens Syndrome: prevalence, risk factors and coronary angiographic variation. A cross-sectional study.BMC cardiovascular disorders · 2024Observational
- Urgent percutaneous coronary intervention in type 2 Wellens' syndrome: A case report of an atypical presentation in an elderly patient.SAGE open medical case reports · 2024Article
- Progression From Patterns A to B in Wellens Syndrome: Electrocardiographic Progression in Wellens Syndrome.JACC. Case reports · 2023Article
- Wellens syndrome progressing from a very subtle type A to a classic type B Wellens pattern.Cardiovascular revascularization medicine : including molecular interventions · 2023Article
- A Case of Wellens' Syndrome.Cureus · 2023Article
- Characteristics of Wellens' Syndrome in the Current PCI Era: A Single-Center Retrospective Study.Emergency medicine international · 2023Article
- Wellens Syndrome: A Possible Precursor.Cureus · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFew studies with large sample sizes are available regarding patients with Wellens' syndrome. Therefore, we sought to assess the current incidence, risk factors, clinical presentation and long-term outcomes of this population.
methodsAmong a total of 3528 patients with ACS who underwent angioplasty from 2017 to 2019 in our centre, 2127 NSTE-ACS patients with culprit LAD vessels were enrolled in this study. According to electrocardiographic criteria, the patients were divided into a Wellens' group (n = 200) and non-Wellens' group (n = 1927). The primary endpoint was cardiac death; the secondary endpoint was MACCE, a composite of all-cause death, cardiac death, recurrent myocardial infarction, target lesion revascularization, heart failure and stroke.
resultsThe incidence of Wellens' syndrome was 5.7% (200 of 3528) of all ACS patients. Wellens' syndrome more often manifested as NSTEMI (69% vs. 17.5%, P < 0.001). The percentages of preexisting coronary heart disease (39.6% vs. 23%) and previous PCI (19.5% vs. 9%) were significantly higher in the non-Wellens' group than in the Wellens' group (all P < 0.001). More importantly, the proportion of early PCI was higher in the Wellens' group (68% vs. 59.3%, P = 0.017). At a median follow-up of 24 months, Wellens' syndrome was not associated with an increased risk of MACCE (P = 0.05) or cardiac death (P = 0.188).
conclusionsThe presence of Wellens' syndrome is not definitively associated with adverse prognosis in patients with NSTE-ACS. Age ≥ 65 years, diabetes, NSTEMI, eGFR < 60 ml/min and left main disease are associated with the incidence of cardiac death. Early recognition and aggressive intervention are critical, as they may help to attenuate adverse outcomes.
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