ArticleJournal of bacteriology1987
Effect of cell cycle position on thermotolerance in Saccharomyces cerevisiae.
Article in Journal of bacteriology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.
- Pooled it
- Heat shock proteins and DNA repair mechanisms: an updated overview.Cell stress & chaperones · 2018Review
- Quantitative proteomic comparison of stationary/G0 phase cells and tetrads in budding yeast.Scientific reports · 2016Article
- Differentiated cytoplasmic granule formation in quiescent and non-quiescent cells upon chronological aging.Microbial cell (Graz, Austria) · 2016Article
- The Cytosolic pH of Individual Saccharomyces cerevisiae Cells Is a Key Factor in Acetic Acid Tolerance.Applied and environmental microbiology · 2015Article
- Uncoupling reproduction from metabolism extends chronological lifespan in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Adaptive evolution of an industrial strain of Saccharomyces cerevisiae for combined tolerance to inhibitors and temperature.Biotechnology for biofuels · 2013Article
- Biology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system.Microbiology and molecular biology reviews : MMBR · 2012Review
- Single-cell analysis of S. cerevisiae growth recovery after a sublethal heat-stress applied during an alcoholic fermentation.Journal of industrial microbiology & biotechnology · 2011Article
- A low-cost procedure for production of fresh autochthonous wine yeast.Journal of industrial microbiology & biotechnology · 2011Article
- Transcriptional regulation in yeast during diauxic shift and stationary phase.Omics : a journal of integrative biology · 2010Review
- Biotechnological properties of distillery and laboratory yeasts in response to industrial stresses.Journal of industrial microbiology & biotechnology · 2010Article
- Delayed correlation of mRNA and protein expression in rapamycin-treated cells and a role for Ggc1 in cellular sensitivity to rapamycin.Molecular & cellular proteomics : MCP · 2010Article
- Hsp90 nuclear accumulation in quiescence is linked to chaperone function and spore development in yeast.Molecular biology of the cell · 2010Article
- Slow growth induces heat-shock resistance in normal and respiratory-deficient yeast.Molecular biology of the cell · 2009Article
- Candida albicans biofilms produce antifungal-tolerant persister cells.Antimicrobial agents and chemotherapy · 2006Article
- The BAR domain proteins: molding membranes in fission, fusion, and phagy.Microbiology and molecular biology reviews : MMBR · 2006Review
- "Sleeping beauty": quiescence in Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 2004Review
- Isolation and characterization of a freeze-tolerant diploid derivative of an industrial baker's yeast strain and its use in frozen doughs.Applied and environmental microbiology · 2002Article
- Smy1p, a kinesin-related protein that does not require microtubules.The Journal of cell biology · 1998Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We showed that the heat killing curve for exponentially growing Saccharomyces cerevisiae was biphasic. This suggests two populations of cells with different thermal killing characteristics. When exponentially growing cells separated into cell cycle-specific fractions via centrifugal elutriation were heat shocked, the fractions enriched in small unbudded cells showed greater resistance to heat killing than did other cell cycle fractions. Cells arrested as unbudded cells fell into two groups on the basis of thermotolerance. Sulfur-starved cells and the temperature-sensitive mutants cdc25, cdc33, and cdc35 arrested as unbudded cells were in a thermotolerant state. Alpha-factor-treated cells arrested in a thermosensitive state, as did the temperature-sensitive mutant cdc36 when grown at the restrictive temperature. cdc7, which arrested at the G1-S boundary, arrested in a thermosensitive state. Our results suggest that there is a subpopulation of unbudded cells in exponentially growing cultures that is in G0 and not in G1 and that some but not all methods which cause arrest as unbudded cells lead to arrest in G0 as opposed to G1. It has been shown previously that yeast cells acquire thermotolerance to a subsequent challenge at an otherwise lethal temperature during a preincubation at 36 degrees C. We showed that this acquisition of thermotolerance was corrected temporally with a transient increase in the percentage of unbudded cells during the preincubation at 36 degrees C. The results suggest a relationship between the heat shock phenomenon and the cell cycle in S. cerevisiae and relate thermotolerance to transient as well as to more prolonged residence in the G0 state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.