Evidence map›Paper›PMID 35429606›Full record

ArticleBrain, behavior, and immunity2022

Neural circuits mediating circulating interleukin-1β-evoked fever in the absence of prostaglandin E2 production.

Clarissa M D Mota, Christopher J Madden

Open access · greenAbstract read
In one paragraph

Article in Brain, behavior, and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Chronic Pain and Cognitive Dysfunction: Clinical Implement, Mechanism, and Therapeutic Strategy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Modulation of the Acute Inflammatory Response Induced by theAntibiotics (Basel, Switzerland) · 2023
    Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Clarissa M D MotaDepartment of Neurological Surgery, Oregon Health & Science University, Portland, OR, United States.
Christopher J MaddenDepartment of Neurological Surgery, Oregon Health & Science University, Portland, OR, United States. Electronic address: maddench@ohsu.edu.
Oregon Health & Science University · US

Funding

Neural mechanisms in high fat diet impairment of brown adipose tissue activityR01DK112198 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI MADDEN, CHRISTOPHER J · 2018 to 2022
$2.1M
NIDDK NIH HHS R01 DK112198
6 · The paper itself

Abstract

Infectious diseases and inflammatory conditions recruit the immune system to mount an appropriate acute response that includes the production of cytokines. Cytokines evoke neurally-mediated responses to fight pathogens, such as the recruitment of thermoeffectors, thereby increasing body temperature and leading to fever. Studies suggest that the cytokine interleukin-1β (IL-1β) depends upon cyclooxygenase (COX)-mediated prostaglandin E

Indexed as

DinoprostoneFeverInterleukin-1betaAdipose Tissue, BrownAnimalsHypothalamusIndomethacinRatsRats, Sprague-DawleySympathetic Nervous SystemThermogenesisDinoprostoneIndomethacinInterleukin-1betaCyclooxygenaseCytokineFeverInflammationSympathetic nervous system

Identifiers

PMID35429606
PMCPMC9524517
OpenAlexW4223986355

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.