Evidence map›Paper›PMID 35429520›Full record

ArticleJournal of affective disorders2022

Intergenerational transmission of maternal childhood adversity and depression on children's internalizing problems.

Danielle Roubinov, Dillon Browne, Kaja Z LeWinn, Nadra Lisha, W Alex Mason, Nicole R Bush

Abstract read
In one paragraph

Article in Journal of affective disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Supportive parenting moderates the link between parents' and children's internalizing symptoms in families of color.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Targeted Research and Treatment Implications in Women With Depression.Focus (American Psychiatric Publishing) · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Danielle RoubinovDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, United States. Electronic address: danielle.roubinov@ucsf.edu.
Dillon BrowneDepartment of Psychology, University of Waterloo, Waterloo, Ontario, Canada; Centre for Mental Health Research & Treatment, University of Waterloo, Waterloo, Ontario, Canada.
Kaja Z LeWinnDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, United States.
Nadra LishaDepartment of General Internal Medicine, University of California, San Francisco, CA, United States.
W Alex MasonUniversity of Tennessee Health Science Center, Memphis, TN, United States.
Nicole R BushDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, United States; Department of Pediatrics, University of California, San Francisco, United States.

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUH3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2018 to 2022
$37.3M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUG3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2016 to 2017
$5.1M
Maternal Traumatic Stress, Oxidative Stress, Antioxidant Exposures, and Child Asthma and Lung FunctionR01HL132338 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CARROLL, KECIA NICOLE, WRIGHT, ROSALIND J · 2017 to 2021
$3.8M
Pregnancy Folate Status & Early Childhood Respiratory & Atopic Disease OutcomesR01HL109977 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CARROLL, KECIA NICOLE · 2011 to 2015
$3.4M
From risk to resilience: understanding and altering profiles of multisystem stress physiology to protect children vulnerable to internalizing disordersK23MH113709 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROUBINOV, DANIELLE S. · 2018 to 2022
$961k
NCATS NIH HHS UL1 TR004419NHLBI NIH HHS R01 HL109977NHLBI NIH HHS R01 HL132338NIH HHS UG3 OD023271NIH HHS UH3 OD023271NIMH NIH HHS K23 MH113709
6 · The paper itself

Abstract

objectiveChildhood trauma exacts a lasting toll on one's own mental health and the health of one's offspring; however, limited research has examined the pathways through which this intergenerational transmission occurs. This study aimed to identify the transactions and mechanisms that link maternal early life trauma, maternal depressive symptoms, and children's internalizing symptoms.

methodA pregnancy cohort of N = 1462 mothers (66% Black, 32% White, 2% Other race) reported their childhood trauma exposure and depressive symptoms during pregnancy. Maternal depressive and children's internalizing symptoms were measured repeatedly when offspring were 12, 24, 36, and 48-60 months of age. A path model tested the transactional associations between maternal and child symptomatology and mediation of maternal childhood trauma on offspring symptoms via maternal depressive symptoms.

resultsMothers' childhood trauma history was related to greater prenatal and postnatal (12 and 24 months) maternal depressive symptoms, which were prospectively associated with offspring internalizing problems at 36 and 48-60 months. Child-directed effects on maternal depressive symptoms were not observed. The association of maternal trauma on children's internalizing at 36 months was mediated by maternal depressive symptoms at 24 months. LIMITATIONS: Assessments of the key study variables were provided by mothers. Childhood trauma was evaluated retrospectively.

conclusionWomen's experiences of adversity in childhood have persistent and cumulative effects on their depression during the transition to parenthood, which is associated with risk for children's internalizing. Given the two-generation influence of maternal childhood trauma exposure, attending to its impact may protect both caregivers and their children.

Indexed as

Adverse Childhood ExperiencesDepressionFemaleHumansMental HealthMothersPregnancyRetrospective StudiesAdverse childhood experiencesChild internalizingIntergenerational trauma transmissionMaternal depressionPrenatal programming

Identifiers

PMID35429520
PMCPMC9357423

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.