Evidence map›Paper›PMID 35429501›Full record

ArticleThe Journal of biological chemistry2022

Mitogen-activated protein kinase phosphatase-1 controls PD-L1 expression by regulating type I interferon during systemic Escherichia coli infection.

Timothy J Barley, Parker R Murphy, Xiantao Wang, Bridget A Bowman, Justin M Mormol, Carli E Mager, Sean G Kirk, Charles J Cash, Sarah C Linn, Xiaomei Meng and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Timothy J BarleyCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Parker R MurphyCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Xiantao WangLaboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, Maryland, USA.
Bridget A BowmanCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Justin M MormolCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Carli E MagerCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Sean G KirkCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Charles J CashCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Sarah C LinnCombined Anatomic Pathology Residency/Graduate Program, Department of Veterinary Biosciences, The Ohio State University College of Veterinary Medicine, Columbus, Ohio, USA; Kidney and Urinary Tract Center, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Xiaomei MengCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Leif D NelinCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA.
Bernadette ChenCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA.
Markus HafnerLaboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, Maryland, USA.
Jian ZhangDepartment of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Yusen LiuCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA. Electronic address: yusen.liu@nationwidechildrens.org.
Nationwide Children's Hospital · USNational Institutes of Health · USUniversity of Iowa · US

Funding

Integration of the results from systems-level determination of cis-acting elements into high-resolution maps of posttranscriptional regulatory events.ZIAAR041205 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI HAFNER, MARKUS · 2016 to 2025
$5.5M
The role of AU-rich element binding proteins in shaping target mRNA expressionZIAAR041200 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI HAFNER, MARKUS · 2014 to 2023
$5.1M
Regulation of PDE3 in the Pathobiology of Pulmonary HypertensionR01HL136963 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI CHEN, BERNADETTE · 2018 to 2022
$2.4M
Regulation of Innate Immune System Sensing of C. Albicans InfectionsR01AI123253 · NIAID · UNIVERSITY OF IOWA · PI WALDSCHMIDT, THOMAS J · 2016 to 2020
$2.1M
Regulation and Function of Mkp-1 During Sepsis.R01AI124029 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI LIU, YUSEN · 2017 to 2021
$1.9M
Role of Protein Ubiquitination in SepsisR01AI121196 · NIAID · UNIVERSITY OF IOWA · PI ZHANG, JIAN · 2016 to 2020
$1.7M
Mkp-1 suppresses immune checkpoint protein PD-L1 to prevent sepsis-associated immune dysfunction and mortalityR21AI142885 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI LIU, YUSEN · 2019 to 2020
$418k
NHLBI NIH HHS R01 HL136963NIAID NIH HHS R01 AI121196NIAID NIH HHS R01 AI123253NIAID NIH HHS R01 AI124029NIAID NIH HHS R21 AI142885
6 · The paper itself

Abstract

Mitogen-activated protein kinase phosphatase 1 (Mkp-1) KO mice produce elevated cytokines and exhibit increased mortality and bacterial burden following systemic Escherichia coli infection. To understand how Mkp-1 affects immune defense, we analyzed the RNA-Seq datasets previously generated from control and E. coli-infected Mkp-1

Indexed as

B7-H1 AntigenDual Specificity Phosphatase 1Escherichia coli InfectionsGene Expression RegulationInterferon Type IAnimalsEscherichia coliMiceB7-H1 AntigenDual Specificity Phosphatase 1Interferon Type Iinfectioninflammationinterferonphosphatasesepsis

Identifiers

PMID35429501
PMCPMC9108994
OpenAlexW4223984968

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.