ArticleCancer immunology, immunotherapy : CII2022
Role of the cGAS-STING pathway in regulating the tumor-immune microenvironment in dMMR/MSI colorectal cancer.
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Article in Cancer immunology, immunotherapy : CII, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
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Who cites it
31 citing papers in PubMed, 65 citations in OpenAlex.
- cGAS-STING pathway activation drives the cold-to-hot tumor transition and sensitizes immunotherapy.Cancer biology & medicine · 2026Review
- Tumor-draining lymph nodes shape the tumor microenvironment through enrichment of tumor-reactive effector-exhausted CD8Signal transduction and targeted therapy · 2026Article
- NOVA1 Activation Modulates the Tumor Immune Microenvironment through STING Phosphorylation in Head and Neck Squamous Cell Carcinoma.Cancer research and treatment · 2026Article
- C5aR1 and cGAS/STING and their possible involvement in radiosensitivity of colorectal cancer.iScience · 2026Review
- Lipid metabolism: a potential checkpoint for cGAS-STING regulation in colorectal cancer.Frontiers in immunology · 2026Review
- The cGAS-STING pathway in cancer immunotherapy: prognostic value and therapeutic potential.Frontiers in immunology · 2026Review
- The cGAS-STING pathway in tumor immunity: dual roles, regulatory mechanisms, and precision therapeutic strategies.Frontiers in pharmacology · 2026Review
- The mitochondrial DNA-cGAS-STING axis in colorectal cancer: a focused review of context-dependent roles and therapeutic opportunities.Frontiers in molecular biosciences · 2026Review
- Identification of Prognosis Signature Based on cGAS-STING Pathway and Its Immunotherapeutic Significance in Lung Adenocarcinoma.Molecular biotechnology · 2026Article
- Mismatch Repair as a Dynamic and Clinically Actionable Vulnerability in Cancer.Cancer research · 2025Review
- The cGAS‒STING pathway in colorectal cancer: bridging innate immunity and therapeutic strategies.Journal of experimental & clinical cancer research : CR · 2025Review
- Nanocarrier-mediated modulation of cGAS-STING signaling pathway to disrupt tumor microenvironment.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Downregulation of cGAS/STING expression in tumor cells by cancer-associated fibroblasts in colorectal cancer.Scientific reports · 2025Article
- Identification of CXCL13 as a Promising Biomarker for Immune Checkpoint Blockade Therapy and PARP Inhibitor Therapy in Ovarian Cancer.Molecular biotechnology · 2025Article
- Cancer cell-extrinsic STING shapes immune-active microenvironment and predicts clinical outcome in gastric cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Article
- Bidirectional regulation of the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon gene pathway and its impact on hepatocellular carcinoma.World journal of gastrointestinal oncology · 2025Article
- OPA3 inhibits the cGAS-STING pathway mediated by mtDNA stress to promote colorectal cancer progression.In vitro cellular & developmental biology. Animal · 2025Article
- cGAS-STING signaling: a therapeutic target in inflammatory bowel disease and related colorectal cancer.Frontiers in immunology · 2025Review
- The effect of African ancestry and mismatch-repair enzyme deficiency/microsatellite instability-high on colorectal adenocarcinoma immune gene expression.Frontiers in gastroenterology (Lausanne, Switzerland) · 2025Article
- High levels of tumor cell-intrinsic STING signaling are associated with increased infiltration of CD8Scientific reports · 2024Article
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Authors and funding
18 authors at 1 institution in 1 country.
Akinao KanetaDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima city, Fukushima, 960-1295, Japan.
Shotaro NakajimaDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima city, Fukushima, 960-1295, Japan. ipsho555@gmail.com.ORCID http://orcid.org/0000-0002-9339-3792
Hirokazu OkayamaDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima city, Fukushima, 960-1295, Japan.
Takuro MatsumotoDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima city, Fukushima, 960-1295, Japan.
Katsuharu SaitoDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima city, Fukushima, 960-1295, Japan.
Tomohiro KikuchiDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima city, Fukushima, 960-1295, Japan.
Eisei EndoDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima city, Fukushima, 960-1295, Japan.
Misato ItoDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima city, Fukushima, 960-1295, Japan.
Kosaku MimuraDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima city, Fukushima, 960-1295, Japan.
Yasuyuki KankeDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima city, Fukushima, 960-1295, Japan.
Motonobu SaitoDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima city, Fukushima, 960-1295, Japan.
Zenichiro SazeDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima city, Fukushima, 960-1295, Japan.
Shotaro FujitaDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima city, Fukushima, 960-1295, Japan.
Wataru SakamotoDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima city, Fukushima, 960-1295, Japan.
Hisashi OnozawaDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima city, Fukushima, 960-1295, Japan.
Tomoyuki MommaDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima city, Fukushima, 960-1295, Japan.
Shinji OhkiDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima city, Fukushima, 960-1295, Japan.
Koji KonoDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima city, Fukushima, 960-1295, Japan.
Fukushima Medical University · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deficient mismatch repair (dMMR)/microsatellite instability (MSI) colorectal cancer (CRC) has high immunogenicity and better prognosis compared with proficient MMR (pMMR)/microsatellite stable (MSS) CRC. Although the activation of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway has been considered to contribute to the high number of CD8
Indexed as
Colorectal NeoplasmsDNA Mismatch RepairChemotactic FactorsCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseHumansInterferonsMembrane ProteinsMicrosatellite InstabilityNucleotidyltransferasesSTING ProteinTumor MicroenvironmentcGAS protein, humanChemotactic FactorsCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseInterferonsMembrane ProteinsNucleotidyltransferasesSTING1 protein, humanSTING ProteinCD8+ TILcGAS-STINGColorectal cancerdMMR/MSIpMMR/MSS
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.