ArticleMolecular ecology resources2022
An ancient truncated duplication of the anti-Müllerian hormone receptor type 2 gene is a potential conserved master sex determinant in the Pangasiidae catfish family.
Article in Molecular ecology resources, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 36 citations in OpenAlex.
- Molecular Characterization and Functional Analysis ofInternational journal of molecular sciences · 2026Article
- Recurrent evolution of ligand-binding domain multiplicity fine-tunes TGFβ signaling in vertebrates.Nature communications · 2026Article
- A chromosome-level reference genome assembly of the giant pangasius (Pangasius sanitwongsei).Scientific data · 2025Article
- A telomere-to-telomere gap-free genome assembly of the striped catfish (Pangasianodon hypophthalmus).Scientific data · 2025Article
- Sex Differentiation and Long-Distance Gene Flow in the Elusive Antarctic FishEcology and evolution · 2025Article
- Multiple Origins of Sex Chromosomes in Nothobranchius Killifishes.Molecular ecology · 2025Article
- Identification of sex-biased MiRNA markers informative of heat-past events.BMC genomics · 2025Article
- The Cause-Effect Model of Master Sex Determination Gene Acquisition and the Evolution of Sex Chromosomes.International journal of molecular sciences · 2025Review
- The origin, evolution, and translocation of sex chromosomes in Silurus catfish mediated by transposons.BMC biology · 2025Article
- Dose-dependent role of AMH and AMHR2 signaling in male differentiation and regulation of sex determination in Spotted knifejaw (Oplegnathus punctatus) with XCell communication and signaling : CCS · 2025Article
- Genomic Anatomy of Homozygous XX Females and YY Males Reveals Early Evolutionary Trajectory of Sex-determining Gene and Sex Chromosomes in Silurus Fishes.Molecular biology and evolution · 2024Article
- Multi-genome comparisons reveal gain-and-loss evolution of anti-Mullerian hormone receptor type 2 as a candidate master sex-determining gene in Percidae.BMC biology · 2024Article
- De novo assembly and characterization of a highly degenerated ZW sex chromosome in the fish Megaleporinus macrocephalus.GigaScience · 2024Article
- A chromosome-level genome assembly of Hong Kong catfish (Clarias fuscus) uncovers a sex-determining region.BMC genomics · 2023Article
- Master-Key Regulators of Sex Determination in Fish and Other Vertebrates-A Review.International journal of molecular sciences · 2023Review
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31 authors at 13 institutions in 8 countries.
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Abstract
The evolution of sex determination (SD) in teleosts is amazingly dynamic, as reflected by the variety of different master sex-determining genes identified. Pangasiids are economically important catfishes in South Asian countries, but little is known about their SD system. Here, we generated novel genomic resources for 12 Pangasiids and characterized their SD system. Based on a Pangasianodon hypophthalmus chromosome-scale genome assembly, we identified an anti-Müllerian hormone receptor type Ⅱ gene (amhr2) duplication, which was further characterized as being sex-linked in males and expressed only in testes. These results point to a Y chromosome male-specific duplication (amhr2by) of the autosomal amhr2a. Sequence annotation revealed that the P. hypophthalmus Amhr2by is truncated in its N-terminal domain, lacking the cysteine-rich extracellular part of the receptor that is crucial for ligand binding, suggesting a potential route for its neofunctionalization. Reference-guided assembly of 11 additional Pangasiids, along with sex-linkage studies, revealed that this truncated amhr2by duplication is a male-specific conserved gene in Pangasiids. Reconstructions of the amhr2 phylogeny suggested that amhr2by arose from an ancient duplication/insertion event at the root of the Siluroidei radiation that is dated to ~100 million years ago. Together these results bring multiple lines of evidence supporting that amhr2by is an ancient and conserved master sex-determining gene in Pangasiids, a finding that highlights the recurrent use of the transforming growth factor β pathway, which is often used for the recruitment of teleost master SD genes, and provides another empirical case towards firther understanding of dynamics of SD systems.
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