Evidence map›Paper›PMID 35429177›Full record

ArticleAmerican journal of hematology2022

Validation of single-gene noninvasive prenatal testing for sickle cell disease.

Erik R Westin, David S Tsao, Oguzhan Atay, Brian P Landry, Patrick P Ye, Devon Chandler-Brown, Brian Alford, Jennifer Hoskovec, Akila Subramaniam, Kevin M Pawlik and 4 more

Abstract readLetter
In one paragraph

Article in American journal of hematology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Proactive management to improve outcomes of high-risk pregnancy in people with sickle cell disease.Hematology. American Society of Hematology. Education Program · 2025
    Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Erik R WestinDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-5771-8457
David S TsaoBillionToOne Inc., Menlo Park, California, USA.
Oguzhan AtayBillionToOne Inc., Menlo Park, California, USA.
Brian P LandryBillionToOne Inc., Menlo Park, California, USA.ORCID 0000-0001-6570-6950
Patrick P YeBillionToOne Inc., Menlo Park, California, USA.ORCID 0000-0003-1160-5016
Devon Chandler-BrownBillionToOne Inc., Menlo Park, California, USA.
Brian AlfordBillionToOne Inc., Menlo Park, California, USA.
Jennifer HoskovecBillionToOne Inc., Menlo Park, California, USA.
Akila SubramaniamDepartment of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Kevin M PawlikDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Spencer G KuperTri-State Perinatology, Deaconess-The Women's Hospital, Newburgh, Indiana, USA.
Frederick D GoldmanDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Tim M TownesDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Vivien A SheehanDepartment of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA.

Funding

Non-invasive prenatal testing of sickle cell diseaseR43HL144322 · NHLBI · BILLIONTOONE, INC. · PI TSAO, DAVID · 2018 to 2018
$224k
NHLBI NIH HHS R43 HL144322
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anemia, Sickle CellNoninvasive Prenatal TestingFemaleHumansPregnancyPrenatal Diagnosis

Identifiers

PMID35429177
PMCPMC9394186

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.