ArticleAnnals of neurology2022
The Optimal Target and Connectivity for Deep Brain Stimulation in Lennox-Gastaut Syndrome.
Article in Annals of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Management of Lennox-Gastaut syndrome with deep brain stimulation: A systematic literature review.Neurosciences (Riyadh, Saudi Arabia) · 2022Pooled it
- Paroxysmal fast activity is a biomarker of treatment response in deep brain stimulation for Lennox-Gastaut syndrome.Epilepsia · 2022Trial
- A guide to neuromodulation in drug-resistant epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2026Review
- Real-world outcomes of responsive neurostimulation in patients with Lennox-Gastaut syndrome: A multicenter retrospective study.Epilepsia open · 2026Observational
- Distinct Spectral and Directional Thalamocortical Network Dynamics Define Focal Seizure Evolution.medRxiv : the preprint server for health sciences · 2026Article
- Centromedian nucleus targeting in the pediatric population treated with thalamic responsive neurostimulation for drug-resistant epilepsy.Epilepsia open · 2026Article
- Local field potentials for target localization in centromedian deep brain stimulation for epilepsy.Frontiers in neuroscience · 2026Article
- Reconstructing the human brain's wiring diagram from axons up.Trends in neurosciences · 2026Review
- Convergent causal mapping unravels distinct frontal networks for visuospatial selective attention.Nature communications · 2025Article
- Thalamic stereoelectroencephalography: safety, accuracy, and thalamocortical connectivity.medRxiv : the preprint server for health sciences · 2025Article
- Optimal stimulation of the thalamic centromedian nucleus in children with Lennox-Gastaut syndrome: patient series.Journal of neurosurgery. Case lessons · 2025Article
- Non-Pharmacological Treatment Methods of Lennox-Gastaut Syndrome-Review of the Literature.Biomedicines · 2025Review
- Delineation of the Centromedian Nucleus for Epilepsy Neuromodulation Using Deep Learning Reconstruction of White Matter-Nulled Imaging.AJNR. American journal of neuroradiology · 2025Article
- A human brain network linked to restoration of consciousness after deep brain stimulation.Nature communications · 2025Article
- Biomarkers for Epilepsy Deep Brain Stimulation.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2025Review
- Article
- Deep Brain Stimulation Therapy for Drug-Resistant Epilepsy: Present and Future Perspectives.Journal of epilepsy research · 2025Review
- Invasive Neurostimulation for the Treatment of Epilepsy.Seminars in neurology · 2025Review
- A generalized epilepsy network derived from brain abnormalities and deep brain stimulation.Nature communications · 2025Article
- The thalamus: Structure, function, and neurotherapeutics.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDeep brain stimulation (DBS) can reduce seizures in Lennox-Gastaut syndrome (LGS). However, little is known about the optimal target and whether efficacy depends on connectivity of the stimulation site. Using outcome data from the ESTEL trial, we aimed to determine the optimal target and connectivity for DBS in LGS.
methodsA total of 20 patients underwent bilateral DBS of the thalamic centromedian nucleus (CM). Outcome was percentage seizure reduction from baseline after 3 months of DBS, defined using three measures (monthly seizure diaries, 24-hour scalp electroencephalography [EEG], and a novel diary-EEG composite). Probabilistic stimulation mapping identified thalamic locations associated with higher/lower efficacy. Two substitute diffusion MRI datasets (a normative dataset from healthy subjects and a "disease-matched" dataset from a separate group of LGS patients) were used to calculate structural connectivity between DBS sites and a map of areas known to express epileptic activity in LGS, derived from our previous EEG-fMRI research.
resultsResults were similar across the three outcome measures. Stimulation was most efficacious in the anterior and inferolateral "parvocellular" CM border, extending into the ventral lateral nucleus (posterior subdivision). There was a positive association between diary-EEG composite seizure reduction and connectivity to areas of a priori EEG-fMRI activation, including premotor and prefrontal cortex, putamen, and pontine brainstem. In contrast, outcomes were not associated with baseline clinical variables.
interpretationEfficacious CM-DBS for LGS is linked to stimulation of the parvocellular CM and the adjacent ventral lateral nucleus, and is associated with connectivity to, and thus likely modulation of, the "secondary epileptic network" underlying the shared electroclinical manifestations of LGS. ANN NEUROL 2022;92:61-74.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.