Evidence map›Paper›PMID 35428979›Full record

Trial reportInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2022

Effect of delayed versus immediate umbilical cord clamping in vaginal delivery at term: A randomized clinical trial.

Carlo De Angelis, Gabriele Saccone, Elisa Sorichetti, Maurizio Alagna, Brunella Zizolfi, Elisabetta Gragnano, Antonietta Legnante, Attilio Di Spiezio Sardo

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04353544 (Effect of Delayed vs Immediate Umbilical Cord Clamping on Maternal Blood Loss in Term Spontaneous Vaginal Delivery), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04353544 nacompletednot on this map

Effect of Delayed vs Immediate Umbilical Cord Clamping on Maternal Blood Loss in Term Spontaneous Vaginal Delivery

TypeinterventionalSponsorFederico II UniversityRan2020 to 2021Enrolled122ConditionsPost Partum HemorrhageArmsdelayed cord clamping
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Effect of delayed versus immediate umbilical cord clamping in vaginal delivery at term: A randomized clinical trial.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2022
    Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Carlo De AngelisDepartment of Maternal and Child Care, Casa di Cura Accreditata Fabia Mater, Rome, Italy.
Gabriele SacconeDepartment of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy.
Elisa SorichettiDepartment of Maternal and Child Care, Casa di Cura Accreditata Fabia Mater, Rome, Italy.
Maurizio AlagnaDepartment of Maternal and Child Care, Casa di Cura Accreditata Fabia Mater, Rome, Italy.
Brunella ZizolfiDepartment of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy.
Elisabetta GragnanoDepartment of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy.ORCID https://orcid.org/0000-0002-7963-2144
Antonietta LegnanteDepartment of Public Health, School of Medicine, University of Naples Federico II, Naples, Italy.
Attilio Di Spiezio SardoDepartment of Public Health, School of Medicine, University of Naples Federico II, Naples, Italy.
Casa di Cura Città di Roma · ITUniversity of Naples Federico II · ITFederico II University Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare maternal blood loss with immediate cord clamping versus delayed cord clamping in women undergoing spontaneous vaginal delivery at term.

methodsParallel group non-blinded randomized trial conducted at a single center in Italy. Women with singleton gestations who underwent spontaneous vaginal delivery at term were eligible and were randomized in a 1:1 ratio to either immediate or delayed cord clamping. In the immediate cord clamping group, cord clamping was within 15 s after birth. In the delayed cord clamping group, cord clamping was after more than 60 s, or when the cord had stopped pulsing. The primary outcome was change in maternal hemoglobin level from the day of delivery to day one after delivery.

resultsA total of 122 participants were enrolled in the trial. There were no significant differences in maternal blood loss as assessed by comparing the decrease in maternal hemoglobin level (mean difference - 0.10 g/dl, 95% confidence interval - 0.28 to 0.08) between the two groups. The mean hemoglobin level at postdelivery day 1 was 11.0 ± 1.5 g/dl in the delayed group and 11.3 ± 1.6 g/dl in the immediate group.

conclusionsDelayed umbilical cord clamping, compared with immediate umbilical cord clamping, resulted in no significant change in maternal hemoglobin level 1 day after delivery.

trial registrationClinicaltrials.gov NCT04353544.

Indexed as

Umbilical CordUmbilical Cord ClampingConstrictionDelivery, ObstetricFemaleHemoglobinsHumansPregnancyTime FactorsHemoglobinscord clampinghemoglobinumbilical cordvaginal delivery

Identifiers

PMID35428979
PMCPMC9790594
OpenAlexW4223952105

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.