Evidence map›Paper›PMID 35428731›Full record

ArticleNeurology2022

Impulsivity Trait Profiles in Patients With Cerebellar Ataxia and Parkinson Disease.

Tiffany X Chen, Chi-Ying R Lin, Megan A Aumann, Yan Yan, Nadia Amokrane, Natasha A Desai, Hakmook Kang, Daniel O Claassen, Sheng-Han Kuo

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Impulsivity in cerebellar ataxia: an online, multidimensional assessment.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Article
  5. Suicidal Ideation in Spinocerebellar Ataxia.The Journal of neuropsychiatry and clinical neurosciences · 2026
    Article
  6. Brain-Behavior Relationships: Neural Mechanisms of Impulsivity and Compulsivity in Neuropsychiatric Disorders.Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology · 2025
    Review
  7. Article
  8. Consensus Paper: Cerebellum and Reward.Cerebellum (London, England) · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Cerebellar impulsivity-compulsivity assessment scale.Annals of clinical and translational neurology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Tiffany X ChenFrom the Department of Neurology (T.X.C., N.A., N.A.D., S.-H.K.) and Initiative of Columbia Ataxia and Tremor (T.X.C., N.A., N.A.D., S.-H.K.), Columbia University Medical Center, New York, NY; Department of Biomedical Engineering (T.X.C.), Johns Hopkins University, Baltimore, MD; Department of Neurology (C.-Y.R.L.), Baylor College of Medicine, Houston, TX; Vanderbilt Brain Institute (M.A.A.), Department of Psychology, Vanderbilt University; and Departments of Neurology (M.A.A., D.O.C.) and Statistics (Y.Y., H.K.), Vanderbilt University Medical Center, Nashville, TN.
Chi-Ying R LinFrom the Department of Neurology (T.X.C., N.A., N.A.D., S.-H.K.) and Initiative of Columbia Ataxia and Tremor (T.X.C., N.A., N.A.D., S.-H.K.), Columbia University Medical Center, New York, NY; Department of Biomedical Engineering (T.X.C.), Johns Hopkins University, Baltimore, MD; Department of Neurology (C.-Y.R.L.), Baylor College of Medicine, Houston, TX; Vanderbilt Brain Institute (M.A.A.), Department of Psychology, Vanderbilt University; and Departments of Neurology (M.A.A., D.O.C.) and Statistics (Y.Y., H.K.), Vanderbilt University Medical Center, Nashville, TN.
Megan A AumannFrom the Department of Neurology (T.X.C., N.A., N.A.D., S.-H.K.) and Initiative of Columbia Ataxia and Tremor (T.X.C., N.A., N.A.D., S.-H.K.), Columbia University Medical Center, New York, NY; Department of Biomedical Engineering (T.X.C.), Johns Hopkins University, Baltimore, MD; Department of Neurology (C.-Y.R.L.), Baylor College of Medicine, Houston, TX; Vanderbilt Brain Institute (M.A.A.), Department of Psychology, Vanderbilt University; and Departments of Neurology (M.A.A., D.O.C.) and Statistics (Y.Y., H.K.), Vanderbilt University Medical Center, Nashville, TN.
Yan YanFrom the Department of Neurology (T.X.C., N.A., N.A.D., S.-H.K.) and Initiative of Columbia Ataxia and Tremor (T.X.C., N.A., N.A.D., S.-H.K.), Columbia University Medical Center, New York, NY; Department of Biomedical Engineering (T.X.C.), Johns Hopkins University, Baltimore, MD; Department of Neurology (C.-Y.R.L.), Baylor College of Medicine, Houston, TX; Vanderbilt Brain Institute (M.A.A.), Department of Psychology, Vanderbilt University; and Departments of Neurology (M.A.A., D.O.C.) and Statistics (Y.Y., H.K.), Vanderbilt University Medical Center, Nashville, TN.
Nadia AmokraneFrom the Department of Neurology (T.X.C., N.A., N.A.D., S.-H.K.) and Initiative of Columbia Ataxia and Tremor (T.X.C., N.A., N.A.D., S.-H.K.), Columbia University Medical Center, New York, NY; Department of Biomedical Engineering (T.X.C.), Johns Hopkins University, Baltimore, MD; Department of Neurology (C.-Y.R.L.), Baylor College of Medicine, Houston, TX; Vanderbilt Brain Institute (M.A.A.), Department of Psychology, Vanderbilt University; and Departments of Neurology (M.A.A., D.O.C.) and Statistics (Y.Y., H.K.), Vanderbilt University Medical Center, Nashville, TN.
Natasha A DesaiFrom the Department of Neurology (T.X.C., N.A., N.A.D., S.-H.K.) and Initiative of Columbia Ataxia and Tremor (T.X.C., N.A., N.A.D., S.-H.K.), Columbia University Medical Center, New York, NY; Department of Biomedical Engineering (T.X.C.), Johns Hopkins University, Baltimore, MD; Department of Neurology (C.-Y.R.L.), Baylor College of Medicine, Houston, TX; Vanderbilt Brain Institute (M.A.A.), Department of Psychology, Vanderbilt University; and Departments of Neurology (M.A.A., D.O.C.) and Statistics (Y.Y., H.K.), Vanderbilt University Medical Center, Nashville, TN.
Hakmook KangFrom the Department of Neurology (T.X.C., N.A., N.A.D., S.-H.K.) and Initiative of Columbia Ataxia and Tremor (T.X.C., N.A., N.A.D., S.-H.K.), Columbia University Medical Center, New York, NY; Department of Biomedical Engineering (T.X.C.), Johns Hopkins University, Baltimore, MD; Department of Neurology (C.-Y.R.L.), Baylor College of Medicine, Houston, TX; Vanderbilt Brain Institute (M.A.A.), Department of Psychology, Vanderbilt University; and Departments of Neurology (M.A.A., D.O.C.) and Statistics (Y.Y., H.K.), Vanderbilt University Medical Center, Nashville, TN.
Daniel O ClaassenFrom the Department of Neurology (T.X.C., N.A., N.A.D., S.-H.K.) and Initiative of Columbia Ataxia and Tremor (T.X.C., N.A., N.A.D., S.-H.K.), Columbia University Medical Center, New York, NY; Department of Biomedical Engineering (T.X.C.), Johns Hopkins University, Baltimore, MD; Department of Neurology (C.-Y.R.L.), Baylor College of Medicine, Houston, TX; Vanderbilt Brain Institute (M.A.A.), Department of Psychology, Vanderbilt University; and Departments of Neurology (M.A.A., D.O.C.) and Statistics (Y.Y., H.K.), Vanderbilt University Medical Center, Nashville, TN.
Sheng-Han KuoFrom the Department of Neurology (T.X.C., N.A., N.A.D., S.-H.K.) and Initiative of Columbia Ataxia and Tremor (T.X.C., N.A., N.A.D., S.-H.K.), Columbia University Medical Center, New York, NY; Department of Biomedical Engineering (T.X.C.), Johns Hopkins University, Baltimore, MD; Department of Neurology (C.-Y.R.L.), Baylor College of Medicine, Houston, TX; Vanderbilt Brain Institute (M.A.A.), Department of Psychology, Vanderbilt University; and Departments of Neurology (M.A.A., D.O.C.) and Statistics (Y.Y., H.K.), Vanderbilt University Medical Center, Nashville, TN. sk3295@cumc.columbia.edu.ORCID 0000-0002-9412-931X
Allen Institute for Brain Science · US

Funding

Targeting Cerebellar Endoplasmic Reticulum Calcium Handling in Essential TremorR01NS124854 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PHYLLIS L FAUST, Sheng-Han Kuo · 2022 to 2026
$2.9M
Targeting Cerebellar Excitatory Synapses for Tremor ProgressionR01NS118179 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUO, SHENG-HAN · 2020 to 2024
$2.2M
Cerebellar Circuitry in the Pathophysiology of TremorR01NS104423 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUO, SHENG-HAN · 2018 to 2022
$2.0M
NINDS NIH HHS R01 NS104423NINDS NIH HHS R01 NS118179NINDS NIH HHS R01 NS124854
6 · The paper itself

Abstract

BACKGROUND AND

objectivesIndividuals with cerebellar ataxia (CA) can develop impulsive behavioral symptoms, often resulting in negative interpersonal consequences, detrimentally affecting their quality of life. Limited evidence exists concerning impulsivity in CA and its associated behavioral changes. We assessed impulsive traits in CA using the Barratt Impulsivity Scale (BIS-11) and compared them with those of Parkinson disease (PD) to investigate the differences in the impulsive trait profiles between CA and PD.

methodsWe conducted a dual-center cross-sectional study with individuals with CA and PD enrolled through consecutive sampling from movement disorders clinics at Columbia University Medical Center and Vanderbilt University Medical Center, respectively. Age-matched controls were recruited at the respective institutions. Participants were excluded if they had prior or comorbid neurologic and psychiatric diseases known to be associated with impulsivity. All participants completed the BIS-11 questionnaire as a measure of impulsive traits. We used a general linear model and a least absolute shrinkage and selection operation regression to compare the total, subscale, and individual items of the BIS-11 scores between groups. Subgroup analyses were performed to isolate cerebellar contributions to impulsivity from potential effects of extracerebellar pathology and dopaminergic dysfunction or medications.

resultsA total of 190 participants-90 age-matched controls, 50 participants with CA, and 50 with PD-completed the assessments. Persons with CA reported 9.7% higher BIS-11 scores than controls ( DISCUSSION: Impulsivity in CA is uniquely driven by the nonplanning trait, unlike in PD. This suggests that the cerebellum and basal ganglia may differentially govern impulsive behaviors with the cerebellum contributing to the brain circuitry of impulsivity in a domain-specific manner.

Indexed as

Cerebellar AtaxiaParkinson DiseaseCross-Sectional StudiesHumansImpulsive BehaviorQuality of Life

Identifiers

PMID35428731
PMCPMC9280994
OpenAlexW4223970741

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.