ArticleBiological psychiatry2022
The Effects of Prenatal Exposure to Neighborhood Crime on Neonatal Functional Connectivity.
Article in Biological psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Maternal Mental Health and Offspring Brain Development: An Umbrella Review of Prenatal Interventions.Biological psychiatry · 2023Pooled it
- Prenatal maternal psychological distress is associated with neurodevelopmental outcomes in toddlers with congenital heart disease.Pediatric research · 2026Article
- Prenatal Psychosocial Distress Interacting with Postnatal Maternal Sensitivity in Shaping Infant Observed Affect and RSA Profiles.Developmental psychobiology · 2026Article
- The promise of infant MRI in psychiatry: toward a framework for neural network measures in early emotional and behavioral risk identification and new intervention targets.Molecular psychiatry · 2026Review
- Social Determinants of Health, the developing brain, and risk and resilience for psychopathology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Stress during the first 1,000 days of life in humans, when everything begins.Frontiers in human neuroscience · 2026Review
- Social determinants impact both viral infections and brain development.Pediatric research · 2025Review
- Social Determinants of Health and Early Brain Development.Pediatric clinics of North America · 2025Review
- Weaving Invisible Threads: The Impact of Caregiver Trauma on Parenting and Child Brain Development.Brain sciences · 2025Review
- The long-term correlates of developmental stress on whole-brain functional connectivity during emotion regulation.Translational psychiatry · 2025Article
- Prenatal Stress and Maternal Role in Neurodevelopment.Annual review of developmental psychology · 2024Article
- Advances in fetal and neonatal neuroimaging and everyday exposures.Pediatric research · 2024Review
- Prenatal Social Determinants of Health: Narrative review of maternal environments and neonatal brain development.Pediatric research · 2024Review
- Greater Neighborhood Disadvantage Is Associated with Alterations in Fetal Functional Brain Network Structure.The Journal of pediatrics · 2024Observational
- Longitudinal effects of prenatal substance use and environmental stressors on executive functioning in low-income African American adolescents: A latent growth modeling analysis.Brain and cognition · 2024Article
- How does the macroenvironment influence brain and behaviour-a review of current status and future perspectives.Molecular psychiatry · 2024Review
- Assessing prenatal and early childhood social and environmental determinants of health in the HEALthy Brain and Child Development Study (HBCD).Developmental cognitive neuroscience · 2024Article
- Prenatal environment is associated with the pace of cortical network development over the first three years of life.Nature communications · 2024Article
- Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy.Molecular psychiatry · 2024Review
- Neighborhood Crime and Externalizing Behavior in Toddlers: A Longitudinal Study With Neonatal fMRI and Parenting.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Article
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Authors and funding
12 authors at 3 institutions in 1 country.
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Abstract
backgroundMaternal exposure to adversity during pregnancy has been found to affect infant brain development; however, the specific effect of prenatal crime exposure on neonatal brain connectivity remains unclear. Based on existing research, we hypothesized that living in a high-crime neighborhood during pregnancy would affect neonatal frontolimbic connectivity over and above other individual- and neighborhood-level adversity and that these associations would be mediated by maternal psychosocial stress.
methodsParticipants included 399 pregnant women, recruited as part of the eLABE (Early Life Adversity, Biological Embedding, and Risk for Developmental Precursors of Mental Disorders) study. In the neonatal period, 319 healthy, nonsedated infants were scanned using resting-state functional magnetic resonance imaging (repetition time = 800 ms; echo time = 37 ms; voxel size = 2.0 × 2.0 × 2.0 mm
resultsLiving in a neighborhood with high property crime during pregnancy was related to weaker neonatal functional connectivity between the thalamus-anterior default mode network (aDMN) (β = -0.15, 95% CI = -0.25 to -0.04, p = .008). Similarly, high neighborhood violent crime was related to weaker functional connectivity between the thalamus-aDMN (β = -0.16, 95% CI = -0.29 to -0.04, p = .01) and amygdala-hippocampus (β = -0.16, 95% CI = -0.29 to -0.03, p = .02), controlling for other types of adversity. Psychosocial stress partially mediated relationships between the thalamus-aDMN and both violent and property crime.
conclusionsThese findings suggest that prenatal exposure to crime is associated with weaker neonatal limbic and frontal functional brain connections, providing another reason for targeted public policy interventions to reduce crime.
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