ArticleBMC veterinary research2022
Measurement of procalcitonin in saliva of pigs: a pilot study.
Article in BMC veterinary research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Salivary responses to an experimental activation of the HPA axis in pigs: Effects of ACTH on analytes related to stress, immune system, inflammation, redox status and metabolism.Veterinary and animal science · 2026Article
- Thermal imaging: A potential tool for early detection of tail lesions in pigs?Animal welfare (South Mimms, England) · 2026Article
- Changes in saliva and serum analytes in domestic pigs and wild boar experimentally infected with African swine fever virus.Veterinary research · 2025Article
- Associations between health, productive performance and oral fluid biomarkers in commercial pig farms.Porcine health management · 2024Article
- Cortisone in saliva of pigs: validation of a new assay and changes after thermal stress.BMC veterinary research · 2024Article
- Cystatin C, Ammonia, and Bicarbonate Measurements in the Saliva of Pigs: Analytical Validation and Changes inAnimals : an open access journal from MDPI · 2024Article
- Pig Acute Phase Proteins as Non-Antibody Systemic Biomarkers of Intracellular Infections.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Analysing biomarkers in oral fluid from pigs: influence of collection strategy and age of the pig.Porcine health management · 2023Article
- Changes in salivary biomarkers of stress, inflammation, redox status, and muscle damage due to Streptococcus suis infection in pigs.BMC veterinary research · 2023Article
- Changes in Biomarkers of Redox Status in Saliva of Pigs after an Experimental Sepsis Induction.Antioxidants (Basel, Switzerland) · 2022Article
- A Proteomic Approach to Elucidate the Changes in Saliva and Serum Proteins of Pigs with Septic and Non-Septic Inflammation.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundProcalcitonin (PCT) is a widely used biomarker of sepsis in human medicine and can have potential applications in the veterinary field. This study aimed to explore whether PCT could be measured in the saliva of pigs and whether its concentration changes in sepsis. Therefore, a specific assay was developed and analytically validated, and changes in PCT concentration were evaluated in two conditions: a) in an experimental model of sepsis produced by the administration of lipopolysaccharide (LPS) to pigs (n = 5), that was compared with a model of non-septic inflammation induced by turpentine oil (n = 4), and b) in healthy piglets (n = 11) compared to piglets with meningitis (n = 20), a disease that usually involves sepsis and whose treatment often requires large amounts of antibiotics in farms.
resultsThe assay showed coefficients of variation within the recommended limits and adequate linearity after serial sample dilutions. The method's detection limit was set at 68 μg/L, and the lower limit of quantification was 414 μg/L. In the LPS experiment, higher concentrations of PCT were found after 24 h in the animals injected with LPS (mean = 5790 μg/L) compared to those treated with turpentine oil (mean = 2127 μg/L, P = 0.045). Also, animals with meningitis had higher concentrations of PCT (mean = 21515 μg/L) than healthy pigs (mean = 6096 μg/L, P value < 0.0001).
conclusionsAccording to these results, this assay could be potentially used as a tool for the non-invasive detection of sepsis in pigs, which is currently a topic of high importance due to antibiotic use restriction.
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