Evidence map›Paper›PMID 35428284›Full record

ArticleBMC health services research2022

The economic burden of infertility treatment and distribution of expenditures overtime in France: a self-controlled pre-post study.

B Bourrion, H Panjo, P-L Bithorel, E de La Rochebrochard, M François, N Pelletier-Fleury

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC health services research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

B BourrionINSERM, Université Paris-Saclay, UVSQ, CESP, Bâtiment 15/16 Inserm, Hôpital Paul Brousse, 16 Avenue Paul Vaillant Couturier, 94807, Villejuif Cedex, France. bastien.bourrion@gmail.com.
H PanjoINSERM, Université Paris-Saclay, UVSQ, CESP, Bâtiment 15/16 Inserm, Hôpital Paul Brousse, 16 Avenue Paul Vaillant Couturier, 94807, Villejuif Cedex, France.
P-L BithorelINED, 9 Cours des Humanités, 50004, 93322, Aubervilliers Cedex, CS, France.
E de La RochebrochardINSERM, Université Paris-Saclay, UVSQ, CESP, Bâtiment 15/16 Inserm, Hôpital Paul Brousse, 16 Avenue Paul Vaillant Couturier, 94807, Villejuif Cedex, France.
M FrançoisINSERM, Université Paris-Saclay, UVSQ, CESP, Bâtiment 15/16 Inserm, Hôpital Paul Brousse, 16 Avenue Paul Vaillant Couturier, 94807, Villejuif Cedex, France.
N Pelletier-FleuryINSERM, Université Paris-Saclay, UVSQ, CESP, Bâtiment 15/16 Inserm, Hôpital Paul Brousse, 16 Avenue Paul Vaillant Couturier, 94807, Villejuif Cedex, France.
Hôpital Paul-Brousse · FRNational Institute for Demographic Studies · FRCentre de recherche en Epidémiologie et Santé des Populations · FRInserm · FR

Funding

Agence Nationale de la Recherche (ANR) ANR-17-CE36-0011-01
6 · The paper itself

Abstract

backgroundRecent cost studies related to infertility treatment have focused on assisted reproductive technologies. None has examined lower-intensity infertility treatments or analyzed the distribution of infertility treatment expenditures over time. The Purpose of the study was to analyse the size and distribution of infertility treatment expenditures over time, and estimate the economic burden of infertility treatment per 10,000 women aged 18 - 50 in France from a societal perspective.

methodsWe used French National individual medico-administrative database to conduct a self-controlled before-after analytic cohort analysis with 556 incidental women treated for infertility in 2014 matched with 9,903 controls using the exact matching method. Infertility-associated expenditures per woman and per 10,000 women over the 3.5-year follow-up period derived as a difference-in-differences.

resultsThe average infertility related expenditure per woman is estimated at 6,996 (95% CI: 5,755-8,237) euros, the economic burden for 10,000 women at 70.0 million (IC95%: 57.6-82.4) euros. The infertility related expenditures increased from 235 (IC95%: 98-373) euros in semester 0, i.e. before treatment, to 1,509 (IC95%: 1,277-1,741) euros in semester 1, mainly due to ovulation stimulation treatment (47% of expenditure), to reach a plateau in semesters 2 (1,416 (IC95%: 1,161-1,670)) and 3 (1,319 (IC95%: 943-1,694)), where the share of expenses is mainly related to hospitalizations for assisted reproductive technologies (44% of expenditure), and then decrease until semester 6 (577 (IC95%: 316-839) euros).

conclusionThis study informs public policy about the economic burden of infertility estimated at 70.0 million (IC95%: 57.6-82.4) euros for 10,000 women aged between 18 and 50. It also highlights the importance of the share of drugs in infertility treatment expenditures. If nothing is done, the increasing use of infertility treatment will lead to increased expenditure. Prevention campaigns against the preventable causes of infertility should be promoted to limit the use of infertility treatments and related costs.

Indexed as

Health ExpendituresInfertilityAdolescentAdultFemaleFinancial StressFranceHealth Care CostsHumansMaleMiddle AgedYoung AdultCosts and Cost AnalysisInfertilityOvarian stimulationReproductive technique, assisted

Identifiers

PMID35428284
PMCPMC9013027
OpenAlexW4223982827

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.