Evidence map›Paper›PMID 35428258›Full record

Trial reportBMC psychiatry2022

Emotion dysregulation and heart rate variability improve in US veterans undergoing treatment for posttraumatic stress disorder: Secondary exploratory analyses from a randomised controlled trial.

Danielle C Mathersul, Kamini Dixit, R Jay Schulz-Heik, Timothy J Avery, Jamie M Zeitzer, Peter J Bayley

Registry-linked trialOpen access · goldAbstract readRandomized Controlled TrialEquivalence Trial
In one paragraph

Trial report in BMC psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02366403 (Breathing Meditation Intervention for Post-Traumatic Stress Disorder), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02366403 nacompletednot on this map

Breathing Meditation Intervention for Post-Traumatic Stress Disorder

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2015 to 2020Enrolled85ConditionsStress Disorders, Post-TraumaticArmsSKY meditation, CPT-C
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Danielle C MathersulWar Related Illness and Injury Study Center (WRIISC), Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, 94304, USA. danielle.mathersul@murdoch.edu.au.
Kamini DixitWar Related Illness and Injury Study Center (WRIISC), Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, 94304, USA.
R Jay Schulz-HeikWar Related Illness and Injury Study Center (WRIISC), Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, 94304, USA.
Timothy J AveryWar Related Illness and Injury Study Center (WRIISC), Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, 94304, USA.
Jamie M ZeitzerDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Peter J BayleyWar Related Illness and Injury Study Center (WRIISC), Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, 94304, USA.
VA Palo Alto Health Care System · USStanford University · US

Funding

Breathing Meditation Intervention for Post Traumatic Stress DisorderI01RX001485 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI BAYLEY, PETER J. · 2015 to 2021
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RRD VA I01 RX001485
6 · The paper itself

Abstract

backgroundEmotion regulation (ER) is a key process underlying posttraumatic stress disorder (PTSD), yet, little is known about how ER changes with PTSD treatment. Understanding these effects may shed light on treatment processes.

methodsWe recently completed a non-inferiority design randomised controlled trial demonstrating that a breathing-based yoga practice (Sudarshan kriya yoga; SKY) was not clinically inferior to cognitive processing therapy (CPT) across symptoms of PTSD, depression, or negative affect. Here, in secondary exploratory analyses (intent-to-treat N = 85; per protocol N = 59), we examined whether self-reported ER (Difficulties in Emotion Regulation Scale; DERS) and physiological ER (heart rate variability; HRV) improved with treatment for clinically significant PTSD symptoms among US Veterans.

resultsDERS-Total and all six subscales improved with small-to-moderate effect sizes (d = .24-.66) following CPT or SKY, with no differences between treatment groups. Following SKY (but not CPT), HR max-min (average difference between maximum and minimum beats per minute), LF/HF (low-to-high frequency) ratio, and normalised HF-HRV (high frequency power) improved (moved towards a healthier profile; d = .42-.55).

conclusionsTo our knowledge, this is the first study to demonstrate that a breathing-based yoga (SKY) improved both voluntary/intentional and automatic/physiological ER. In contrast, trauma-focused therapy (CPT) only reliably improved self-reported ER. Findings have implications for PTSD treatment and interventions for emotional disorders more broadly.

trial registrationSecondary analyses of ClinicalTrials.gov NCT02366403 .

Indexed as

Stress Disorders, Post-TraumaticVeteransYogaEmotionsHeart RateHumansCognitive processing therapyEmotion regulationHeart rate variabilityHRVPosttraumatic stress disorderPTSDYoga

Identifiers

PMID35428258
PMCPMC9012004
OpenAlexW4206632826

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.