ArticleBMC cardiovascular disorders2022
CRP levels are significantly associated with CRP genotype and estrogen use in The Lifestyle, Biomarker and Atherosclerosis (LBA) study.
Article in BMC cardiovascular disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- Vericiguat on C-reactive Protein Level and Prognosis in Patients with Hypertensive Heart Failure.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024Trial
- Cardiovascular Health Was Moderate in Austrian Adolescents and Showed an Inverse Relationship With High-Sensitivity C-Reactive Protein Levels.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Associations of circulating c-reactive protein levels with central Alzheimer's disease biomarkers.The journal of prevention of Alzheimer's disease · 2026Observational
- C-reactive protein in cardiovascular disease: clinical associations, conformation-dependent biology, and therapeutic perspectives.Frontiers in immunology · 2026Review
- Article
- Association between C10X polymorphism in the CARD8 gene and inflammatory markers in young healthy individuals in the LBA study.BMC cardiovascular disorders · 2024Article
- Chronic Inflammation and Age-Related Hearing: Based on Mendelian Randomization.Journal of inflammation research · 2024Article
- Early elevation of high-sensitivity C-reactive protein as a predictor for cardiovascular disease incidence and all-cause mortality: a landmark analysis.Scientific reports · 2023Article
- Article
- The Impact ofDiagnostics (Basel, Switzerland) · 2023Article
- Mutations on a conserved distal enhancer in the porcine C-reactive protein gene impair its expression in liver.Frontiers in immunology · 2023Article
- Inflammatory markers and the risk of idiopathic sudden sensorineural hearing loss: A Mendelian randomization study.Frontiers in neurology · 2023Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe C-reactive protein (CRP) is an important biomarker for atherosclerosis and single nucleotide polymorphisms (SNPs) in the CRP locus have been associated with altered CRP levels and associated with risk for cardiovascular disease. However, the association between genetic variations in the CRP gene, estrogen use and CRP levels or early signs of atherosclerosis in young healthy individuals is not fully characterized. We aimed to evaluate the influence of five genetic variants on both plasma CRP levels and carotid intima-media thickness (cIMT) values, including aspects on estrogen containing contraceptive use in females.
methodsGenotyping was performed with TaqMan real time PCR and compared with high sensitivity CRP serum levels in 780 Swedish young, self-reported healthy individuals. Haplotypes of the SNPs were estimated with the PHASE v 2.1. The cIMT was measured by 12 MHz ultrasound. The contraceptive use was self-reported.
resultsStrong associations between CRP and genotype were observed for rs3091244, rs1800947, rs1130864, and rs1205 in women (all p < 0.001). In men, only rs1800947 was associated with CRP (p = 0.029). The independent effect of genotypes on CRP remained significant also after adjustment for established risk factors. Female carriers of the H1/ATGTG haplotype had higher CRP than non-carriers. This was specifically pronounced in the estrogen-using group (p < 0.001), and they had also higher cIMT (p = 0.002) than non-carriers but with a small cIMT difference between the haplotype groups (0.02 mm). In parallel, a significant correlation between CRP and cIMT in the estrogen using group was observed (r = 0.194; p = 0.026).
conclusionsEstrogen use, genotypes and haplotypes in the CRP locus are significantly associated with CRP levels. Based on an observed interaction effect between sex/estrogen use and the H1/ATGTG haplotype on CRP, and a marginally thicker cIMT in the estrogen using group, our data suggest that both genotypes and estrogen usage could be involved in arterial wall structural differences. The causality between CRP levels and cIMT remains unclear, and the observed difference in cIMT is not clinically relevant in the present state. Future larger and longitudinal studies may shed further light on the role of more long-term estrogen use and early atherosclerosis.
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