Evidence map›Paper›PMID 35427980›Full record

ArticleDrug and alcohol dependence2022

Suicidal motivations among opioid overdose survivors: Replication and extension.

Hilary S Connery, Roger D Weiss, Margaret L Griffin, Catherine D Trinh, Jungjin Kim, Ian R H Rockett, R Kathryn McHugh

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Association between undetermined intent death classification and county death investigation system for drug poisoning deaths in nine US jurisdictions.Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention · 2026
    Article
  3. Hair cortisol concentrations as a putative biomarker for suicidal behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Hilary S ConneryMcLean Hospital, 115 Mill Street, Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. Electronic address: hconnery@mclean.harvard.edu.
Roger D WeissMcLean Hospital, 115 Mill Street, Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Margaret L GriffinMcLean Hospital, 115 Mill Street, Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Catherine D TrinhMcLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.
Jungjin KimMcLean Hospital, 115 Mill Street, Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Ian R H RockettDepartment of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA; Department of Epidemiology and Biostatistics, School of Public Health, West Virginia University, Morgantown, University of Rochester Medical Center, Rochester, NY, USA.
R Kathryn McHughMcLean Hospital, 115 Mill Street, Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
McLean Hospital · USHarvard University · USUniversity of Rochester Medical Center · US

Funding

Implicit and Explicit Suicidal Cognition and Risk for Opioid OverdoseR21DA046521 · NIDA · MCLEAN HOSPITAL · PI MCHUGH, REBECCA KATHRYN · 2019 to 2020
$451k
NIDA NIH HHS R21 DA046521
6 · The paper itself

Abstract

backgroundSeveral studies suggest suicidal motivation may contribute to opioid overdose fatalities in people with opioid use disorder. In this study, we sought to replicate and extend prior findings suggesting that a desire to die is common prior to nonfatal opioid overdose in people with opioid use disorder.

methodsAdults receiving inpatient detoxification and stabilization who reported a history of opioid overdose (N = 60) completed questions about suicidal cognition prior to their most recent overdose.

resultsApproximately 45% reported some desire to die prior to their most recent overdose, with 20% reporting they had some intention to die. The correlation between these ratings was of a moderate magnitude (ρ = 0.58). Almost 40% of the sample perceived no risk of overdose prior to their most recent overdose event, suggesting a significant underestimation of risk in this population.

conclusionsDesire to die was common in adults with opioid use disorder prior to nonfatal opioid overdose events, and 1 in 5 people with a history of opioid overdose reported intention to die prior to their most recent opioid overdose. Careful assessment of suicidal cognition in this population may improve prevention of opioid overdose deaths.

Indexed as

Drug OverdoseOpiate OverdoseOpioid-Related DisordersAdultAnalgesics, OpioidHumansMotivationSuicidal IdeationSurvivorsAnalgesics, OpioidOpioid use disorderOverdoseSelf-injury mortalitySuicideSuicide prevention

Identifiers

PMID35427980
PMCPMC9106902
OpenAlexW4224060035

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.