Research Note: Virulence gene downregulation and reduced intestinal colonization of Salmonella enterica serovar Typhimurium PHL2020 isolate in broilers by a natural antimicrobial (NeutraPath™).

H Xue, D Wang, B M Hargis, G Tellez-Isaias

Open access · goldAbstract readRandomized Controlled Trial, Veterinary

In one paragraph

Article in Poultry science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.1field-weighted citation impact, top 60% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed, 1 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

H XueAmlan International, Chicago, IL 60061, USA. Electronic address: Hongyu.Xue@Amlan.com.

D WangAmlan International, Chicago, IL 60061, USA.

B M HargisDepartment of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA.

G Tellez-IsaiasDepartment of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA.

Plan International · USUniversity of Arkansas at Fayetteville · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The reduction in antibiotic growth promoter use in poultry, due to antibiotic resistance concerns, has created a need for natural solutions that control enteric pathogens like Salmonella. One of these natural feed additives, a select blend of essential oils, fatty acids, and an enterosorbent mineral (NeutraPath), was assessed for its effects on the intestinal colonization of Salmonella enterica serovar Typhimurium PHL2020 isolate (ST-PHL2020) in broiler chickens and ST-PHL2020 virulence gene expression. An in vitro digestion model simulating the pH and enzymatic conditions of 3 gastrointestinal compartments (crop, proventriculus, and intestine) was first used to evaluate the antibacterial effects of NeutraPath on ST-PHL2020. For the in vivo study, day-old male broilers (n = 90) were randomly allocated to 1 of 3 groups: control or NeutraPath supplemented at 0.25 or 0.5%. The dose rates were chosen to enable observable statistical effects during high Salmonella challenge. All groups were challenged with ST-PHL2020 (10

Indexed as

Anti-Infective AgentsPoultry DiseasesSalmonella entericaSalmonella Infections, AnimalAnimalsAnti-Bacterial AgentsChickensDown-RegulationFluorescein-5-isothiocyanateIntestinesMaleSerogroupVirulenceAnti-Bacterial AgentsAnti-Infective AgentsFluorescein-5-isothiocyanateintestinal colonizationnatural antimicrobialNeutraPathSalmonella Typhimurium PHL2020 isolatevirulence gene expression

Identifiers

PMID35427858

DOI10.1016/j.psj.2022.101822

PMCPMC9019353

OpenAlexW4220880735

What OpenQuestion holds

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.