Evidence map›Paper›PMID 35427769›Full record

ArticleNeuroImage2022

Ultra-high field (10.5T) diffusion-weighted MRI of the macaque brain.

Mark D Grier, Essa Yacoub, Gregor Adriany, Russell L Lagore, Noam Harel, Ru-Yuan Zhang, Christophe Lenglet, Kâmil Uğurbil, Jan Zimmermann, Sarah R Heilbronner

Open access · goldAbstract read
In one paragraph

Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. 10.5 T In Vivo Head Imaging With Universal RF Shimming.Magnetic resonance in medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Mark D GrierDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, United States.
Essa YacoubCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, United States; Center for Neuroengineering, University of Minnesota, Minneapolis, MN 55455, United States.
Gregor AdrianyCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, United States; Center for Neuroengineering, University of Minnesota, Minneapolis, MN 55455, United States.
Russell L LagoreCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, United States.
Noam HarelCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, United States; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, United States.
Ru-Yuan ZhangInstitute of Psychology and Behavioral Science, Shanghai Jiao Tong University, Shanghai 200030, P.R. China; Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, P.R. China; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, United States.
Christophe LengletCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, United States.
Kâmil UğurbilCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, United States; Center for Neuroengineering, University of Minnesota, Minneapolis, MN 55455, United States.
Jan ZimmermannDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, United States; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455, United States; Center for Neuroengineering, University of Minnesota, Minneapolis, MN 55455, United States; Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, United States.
Sarah R HeilbronnerDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, United States; Center for Neuroengineering, University of Minnesota, Minneapolis, MN 55455, United States. Electronic address: heilb028@umn.edu.
University of Minnesota · US

Funding

Using a computational and network neuroscience framework to study pharmacological manipulations of state representation processes in early psychosisP50MH119569 · NIMH · UNIVERSITY OF MINNESOTA · PI A DAVID REDISH, Sophia Vinogradov · 2020 to 2026
$24.5M
Viral Innovation CoreP30DA048742 · NIDA · UNIVERSITY OF MINNESOTA · PI Mark John Thomas · 2020 to 2026
$19.0M
TRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Gregory John Metzger, KAMIL UGURBIL · 2019 to 2026
$11.7M
NEUROSCIENCE TRAINING IN DRUG ABUSE RESEARCHT32DA007234 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Paul G Mermelstein, Jocelyn M Richard · 1986 to 2026
$10.9M
Elementary Neuronal Ensembles to Whole Brain Networks: Ultrahigh Resolution Imaging of Function and Connectivity in Humans - SUPPLEMENTU01EB025144 · NIBIB · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2017 to 2022
$9.7M
Pathophysiology-based approaches to deep brain stimulation for Parkinson's diseaseP50NS098573 · NINDS · UNIVERSITY OF MINNESOTA · PI JOHNSON, MATTHEW DOUGLAS · 2016 to 2020
$9.1M
Revealing functional networks and circuits of the posteromedial cortex withanatomical connectivityR01MH118257 · NIMH · UNIVERSITY OF MINNESOTA · PI HEILBRONNER, SARAH RACHEL · 2019 to 2023
$1.9M
Connectome style neuroimaging in non human primates via novel integrated RF platformsR01EB031765 · NIBIB · UNIVERSITY OF MINNESOTA · PI ZIMMERMANN, JAN · 2022 to 2025
$1.9M
Connectome style neuroimaging in non human primates via novel integrated RF platformsR56EB031765 · NIBIB · UNIVERSITY OF MINNESOTA · PI ZIMMERMANN, JAN · 2021 to 2021
$502k
Platform for ultra-high resolution multi-modal investigations of brain function in the non-human primate at 10.5 TS10MH124728 · NIMH · UNIVERSITY OF MINNESOTA · PI GHOSE, GEOFFREY M · 2021 to 2021
$408k
NIBIB NIH HHS P41 EB027061NIBIB NIH HHS R01 EB031765NIBIB NIH HHS R56 EB031765NIBIB NIH HHS U01 EB025144NIDA NIH HHS P30 DA048742NIDA NIH HHS T32 DA007234NIMH NIH HHS P50 MH119569NIMH NIH HHS R01 MH118257NIMH NIH HHS S10 MH124728NINDS NIH HHS P50 NS098573
6 · The paper itself

Abstract

Diffu0sion-weighted magnetic resonance imaging (dMRI) is a non-invasive imaging technique that provides information about the barriers to the diffusion of water molecules in tissue. In the brain, this information can be used in several important ways, including to examine tissue abnormalities associated with brain disorders and to infer anatomical connectivity and the organization of white matter bundles through the use of tractography algorithms. However, dMRI also presents certain challenges. For example, historically, the biological validation of tractography models has shown only moderate correlations with anatomical connectivity as determined through invasive tract-tracing studies. Some of the factors contributing to such issues are low spatial resolution, low signal-to-noise ratios, and long scan times required for high-quality data, along with modeling challenges like complex fiber crossing patterns. Leveraging the capabilities provided by an ultra-high field scanner combined with denoising, we have acquired whole-brain, 0.58 mm isotropic resolution dMRI with a 2D-single shot echo planar imaging sequence on a 10.5 Tesla scanner in anesthetized macaques. These data produced high-quality tractograms and maps of scalar diffusion metrics in white matter. This work demonstrates the feasibility and motivation for in-vivo dMRI studies seeking to benefit from ultra-high fields.

Indexed as

Diffusion Magnetic Resonance ImagingMacacaAnimalsBrainEcho-Planar ImagingHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingDiffusion MRINonhuman primateStructural connectivityTractography

Identifiers

PMID35427769
PMCPMC9446284
OpenAlexW4223483190

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.