ArticleCancer cell2022
Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells.
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Article in Cancer cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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134citing papers in PubMed, 1 pooled it
12.8field-weighted citation impact, top 1% of its field
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Who cites it
134 citing papers in PubMed, 1 synthesis or guideline pooled it, 162 citations in OpenAlex.
- The soldiers needed to be awakened: Tumor-infiltrating immune cells.Frontiers in genetics · 2022Pooled it
- Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Personalized neoantigen-targeting cancer vaccines in ovarian cancer: a phase 1 trial.Nature medicine · 2026Article
- Distinct migratory dendritic cell subsets cooperate to prime tissue-resident memory-like CD8⁺ T cells in mouse tumors.Nature communications · 2026Article
- Tumor-infiltrating plasma cell profiling after PD-1 blockade reveals tumor-specific antibodies.Cancer cell · 2026Article
- Spatiotemporal immune heterogeneity and precision immunotherapy for ovarian cancer.Clinical and translational medicine · 2026Review
- Immunotherapy in Gynecologic Cancers: Current Evidence, Biomarker-Driven Practice, and Future Directions.Cancers · 2026Review
- Article
- A Multistep Immune-Competent Genetically Engineered Mouse Model Reveals Phenotypic Plasticity in Uveal Melanoma.Cancer research · 2026Article
- GZMK-expressing tissue-resident memory CD8+ T cells participate in human intestinal acute graft-versus-host disease.JCI insight · 2026Article
- Transcriptomic analysis of tissue-resident memory T cells of the fallopian tube reveals a precursor immune surveillance network for ovarian cancer prevention.Nature communications · 2026Article
- Article
- Rethinking ovarian cancer III: the past decade and future directions.Nature reviews. Cancer · 2026Review
- Immune Evasion in Ovarian Cancer Peritoneal Metastasis: Mechanisms and Biomarker-Guided Therapeutic Matching.Journal of cellular physiology · 2026Review
- Extracellular Matrix-Related Gene Signature Implied Immunosuppressive Status and Adverse Survival in Diffuse Glioma Patients.Cancers · 2026Article
- Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function.Cell · 2026Article
- Unmasking FCGR2B as a high-grade serous ovarian cancer specific marker of immune suppression and tumor progression through multi-omics mining.Translational oncology · 2026Article
- Spatial multi-omics reveals a cancer-associated fibroblast-T cell niche sustaining tissue-resident immunity in clear-cell renal cell carcinoma.Translational andrology and urology · 2026Article
- Terminal T-cell exhaustion predicts tumor control independent of immunotherapy in ovarian cancer.NPJ precision oncology · 2026Article
- Galangin-loaded biomimetic dendritic cells membrane nanovaccine reprograms the ovarian cancer microenvironmentMaterials today. Bio · 2026Article
74 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
25 authors at 3 institutions in 2 countries.
Carmen M AnadonDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
Xiaoqing YuDepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Kay HänggiDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
Subir BiswasDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
Ricardo A ChaurioDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
Alexandra MartinDepartment of Gynecologic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Kyle K PayneDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
Gunjan MandalDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
Patrick InnamaratoDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
Carly M HarroDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
Jessica A MineDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
Kimberly B SprengerDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
Carla CortinaDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
John J PowersDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
Tara Lee CostichDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
Bradford A PerezDepartment of Radiation Therapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Chandler D GatenbeeDepartment of Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Sandhya PrabhakaranDepartment of Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Douglas MarchionDepartment of Tissue Core, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Mirjam H M HeemskerkDepartment of Hematology, Leiden University Medical Center, Leiden, the Netherlands.
Tyler J CurielDepartment of Medicine, UT Health San Antonio, San Antonio, TX 78229, USA.
Alexander R AndersonDepartment of Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Robert M WenhamDepartment of Gynecologic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Paulo C RodriguezDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
Jose R Conejo-GarciaDepartment of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA; Department of Gynecologic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA; Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA. Electronic address: jose.conejo-garcia@moffitt.org.
Moffitt Cancer Center · USLeiden University Medical Center · NLThe University of Texas Health Science Center at San Antonio · US
Funding
TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5MTumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Dario C Altieri · 1985 to 2026
$75.9MIMMUNOBIOLOGY OF NORMAL AND NEOPLASTIC LYMPHOCYTEST32CA009140 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Malay Haldar, WARREN S PEAR · 1985 to 2026
$16.1MVascular Leukocytes Influence the Tumor MicroenvironmentR01CA124515 · NCI · WISTAR INSTITUTE · PI Jose R Conejo-Garcia · 2007 to 2026
$7.1MRapid Exoproteome Antigen Profiling of antibodies produced in the ovarian cancer microenvironmentU01CA232758 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI CONEJO-GARCIA, JOSE R · 2018 to 2022
$4.1MInitiation and Evolution of the Ovarian Cancer MicroenvironmentR01CA157664 · NCI · WISTAR INSTITUTE · PI CONEJO-GARCIA, JOSE R · 2011 to 2020
$3.8MTargetable epigenetic mechanism driving Cutaneous T cell LymphomaR01CA240434 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI CONEJO-GARCIA, JOSE R, PINILLA, JAVIER · 2019 to 2023
$2.6MPlant-derived extracts regulate immunosuppressive myelopoiesis in Breast cancer patientsR01CA262121 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI RODRIGUEZ, PAULO CESAR · 2021 to 2025
$2.1MFunctional reprogramming of tumor-MDSC through antibody-based therapies targeting Notch ligandsR01CA233512 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI RODRIGUEZ, PAULO CESAR · 2019 to 2023
$2.0MDeveloping a Human in Mouse Cancer Model with a Completely Humanized StromaR01CA211913 · NCI · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI BUCKANOVICH, RONALD J · 2017 to 2020
$1.9MEffects of Common Polymorphisms in Immune Sensors in Tumor ImmunosurveillanceR01CA178687 · NCI · WISTAR INSTITUTE · PI CONEJO-GARCIA, JOSE R · 2013 to 2017
$1.9MStress Pathways in Tumors Drive Global MDSC Activity and Survival through ChopR01CA184185 · NCI · LSU HEALTH SCIENCES CENTER · PI RODRIGUEZ, PAULO CESAR · 2015 to 2019
$1.8MNCI NIH HHS K08 CA231454NCI NIH HHS K99 CA266947NCI NIH HHS P30 CA010815NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA124515NCI NIH HHS R01 CA157664NCI NIH HHS R01 CA178687NCI NIH HHS R01 CA184185NCI NIH HHS R01 CA211913NCI NIH HHS R01 CA233512NCI NIH HHS R01 CA240434NCI NIH HHS R01 CA262121NCI NIH HHS T32 CA009140NCI NIH HHS U01 CA232758
Abstract
Despite repeated associations between T cell infiltration and outcome, human ovarian cancer remains poorly responsive to immunotherapy. We report that the hallmarks of tumor recognition in ovarian cancer-infiltrating T cells are primarily restricted to tissue-resident memory (TRM) cells. Single-cell RNA/TCR/ATAC sequencing of 83,454 CD3
Indexed as
Immunologic MemoryOvarian NeoplasmsCD8-Positive T-LymphocytesFemaleHumansLymphocytes, Tumor-InfiltratingMemory T Cellsimmuno-oncologyneoantigenovarian cancertissue-resident memory-like T celltumor-infiltrating lymphocyte
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.