SynthesisPloS one2022
A comparison of qSOFA, SIRS and NEWS in predicting the accuracy of mortality in patients with suspected sepsis: A meta-analysis.
Synthesis in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Sepsis screening tools in resource-limited settings: a systematic review and meta-analysis of diagnostic accuracy in low- and middle-income countries.Frontiers in public health · 2026Pooled it
- Artificial Intelligence-Based Predictive Modeling for Early Detection of Sepsis in Hospitalized Patients: A Systematic Review and Meta-Analysis.Critical care explorations · 2025Pooled it
- Mortality predictors in pediatric emergency department presentations: a systematic review and meta-analysis.BMC emergency medicine · 2025Pooled it
- Significances of miRNAs for predicting sepsis mortality: a meta-analysis.Frontiers in microbiology · 2025Pooled it
- Lessons Learned from Sepsis Microlearning Intervention.Applied clinical informatics · 2025Trial
- Trial
- Article
- Predictive Performance of Sepsis Scoring Tools for In-Hospital Mortality Among Patients With Suspected Sepsis Presenting to the Colonial War Memorial Hospital Emergency Department, Fiji.Emergency medicine Australasia : EMA · 2026Observational
- Factors associated with mortality in older sepsis patients: a nationwide retrospective cohort study in Germany.Age and ageing · 2026Observational
- Sepsis in critically ill dogs: identification of clinical and laboratory risk factors and evaluation of sepsis scoring systems.Journal of veterinary internal medicine · 2026Article
- Service-Specific Heterogeneity in Sepsis Variable Significance and Machine Learning Model Performance: A Stratified Analysis of the BIAlert Cohort.Journal of clinical medicine · 2026Article
- Mortality prediction by quick Sequential Organ Failure Assessment, National Early Warning Score 2, Shock Index, and Modified Shock Index in suspected sepsis: A retrospective study.The Journal of international medical research · 2026Observational
- Clinical Outcomes for Emergency Department Presentations of Sepsis Managed on a Clinical Pathway: A Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2026Review
- Radiological detection rate and clinical impact of thoracoabdominal computed tomography in suspected infection in the emergency department: a retrospective cohort study.BMC emergency medicine · 2026Article
- Challenges in early detection and prognostication of sepsis: new approaches from the emergency department and intensive care unit.EClinicalMedicine · 2026Review
- The Global Impact of Sepsis: Epidemiology, Recognition, Management, and Health System Challenges.Epidemiologia (Basel, Switzerland) · 2026Review
- Development and Internal Validation of a Multivariable Prehospital Prediction Score for Critical Illness Progression and 30-Day Mortality in Non-Traumatic EMS Patients.Journal of healthcare leadership · 2026Article
- Comparative Prognostic Performance of qSOFA and SOFA in Emergency Department Patients With Established Septic Shock.Emergency medicine international · 2026Article
- Shock index-modified qSOFA improves mortality risk stratification in patients with sepsis beyond conventional qSOFA.Frontiers in medicine · 2026Article
- Risk factors for mortality in Stenotrophomonas maltophilia bacteraemia: a 22-year retrospective study in a Japanese acute care hospital.Access microbiology · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo identify and compare prognostic accuracy of quick Sequential Organ Failure Assessment (qSOFA) score, Systemic Inflammatory Response Syndrome (SIRS) criteria, and National Early Warning Score (NEWS) to predict mortality in patients with suspected sepsis.
methodsThis meta-analysis followed accordance with the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. We searched PubMed, EMBASE, Web of Science, and the Cochrane Library databases from establishment of the database to November 29, 2021. The pooled sensitivity and specificity with 95% CIs were calculated using a bivariate random-effects model (BRM). Hierarchical summary receiver operating characteristic (HSROC) curves were generated to assess the overall prognostic accuracy.
resultsData of 62338 patients from 26 studies were included in this meta-analysis. qSOFA had the highest specificity and the lowest sensitivity with a specificity of 0.82 (95% CI: 0.76-0.86) and a sensitivity of 0.46 (95% CI: 0.39-0.53). SIRS had the highest sensitivity and the lowest specificity with a sensitivity of 0.82 (95% CI: 0.78-0.85) and a specificity 0.24 (95% CI: 0.19-0.29). NEWS had both an intermediate sensitivity and specificity with a sensitivity of 0.73 (95% CI: 0.63-0.81) and a specificity 0.52 (95% CI: 0.39-0.65). qSOFA showed higher overall prognostic accuracy than SIRS and NEWS by comparing HSROC curves.
conclusionsAmong qSOFA, SIRS and NEWS, qSOFA showed higher overall prognostic accuracy than SIRS and NEWS. However, no scoring system has both high sensitivity and specificity for predicting the accuracy of mortality in patients with suspected sepsis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.