Evidence map›Paper›PMID 35427362›Full record

ArticlePloS one2022

The Escherichia coli serS gene promoter region overlaps with the rarA gene.

Kanika Jain, Tyler H Stanage, Elizabeth A Wood, Michael M Cox

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Linalool exhibit antimicrobial ability againstCurrent research in microbial sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kanika JainDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0001-9401-0055
Tyler H StanageDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Elizabeth A WoodDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.ORCID 0000-0002-7769-8481
Michael M CoxDepartment of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
University of Wisconsin–Madison · US

Funding

Creation and Repair of Postreplicative DNA GapsRM1GM130450 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Michael M. Cox, MYRON GOODMAN · 2019 to 2026
$10.4M
NIGMS NIH HHS RM1 GM130450
6 · The paper itself

Abstract

Deletion of the entire gene encoding the RarA protein of Escherichia coli results in a growth defect and additional deficiencies that were initially ascribed to a lack of RarA function. Further work revealed that most of the effects reflected the presence of sequences in the rarA gene that affect expression of the downstream gene, serS. The serS gene encodes the seryl aminoacyl-tRNA synthetase. Decreases in the expression of serS can trigger the stringent response. The sequences that affect serS expression are located in the last 15 nucleotides of the rarA gene.

Indexed as

Amino Acyl-tRNA SynthetasesSerine-tRNA LigaseEscherichia coliPromoter Regions, GeneticAmino Acyl-tRNA SynthetasesSerine-tRNA Ligase

Identifiers

PMID35427362
PMCPMC9012371
OpenAlexW4226039482

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.