Evidence map›Paper›PMID 35427215›Full record

ReviewRNA biology2022

Mechanisms of non-coding RNA-modulated alternative splicing in cancer.

Xiaolin Wang, Jinghan Hua, Jingxin Li, Jiahui Zhang, Emmanuel Enoch Dzakah, Guozhen Cao, Wenchu Lin

Open access · goldAbstract readReview
In one paragraph

Review in RNA biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 49 citations in OpenAlex.

  1. Genome stability disrupted by the circRBM39(4,5,6)-RPA2 axis represses breast tumorigenesis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Article
  4. The "cutting edge" of non-canonical RNA splicing.Frontiers in molecular biosciences · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Circular RNAs modulate cancer drug resistance: advances and challenges.Cancer drug resistance (Alhambra, Calif.) · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. RNA therapeutics.RNA biology · 2024
    Article
  16. Review
  17. Review
  18. HOTAIR in colorectal cancer: structure, function, and therapeutic potential.Medical oncology (Northwood, London, England) · 2023
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Xiaolin WangHigh Magnetic Field Laboratory, Hefei Institutes of Physical Science (Hips), Chinese Academy of Sciences, Hefei, Anhui, P. R. China.
Jinghan HuaHigh Magnetic Field Laboratory, Hefei Institutes of Physical Science (Hips), Chinese Academy of Sciences, Hefei, Anhui, P. R. China.
Jingxin LiUniversity of Science and Technology of China, Hefei, Anhui, P. R. China.
Jiahui ZhangHigh Magnetic Field Laboratory, Hefei Institutes of Physical Science (Hips), Chinese Academy of Sciences, Hefei, Anhui, P. R. China.
Emmanuel Enoch DzakahDepartment of Molecular Biology and Biotechnology, School of Biological Sciences, College of Agriculture and Natural Sciences, University of Cape Coast, Cape Coast, Ghana.
Guozhen CaoHigh Magnetic Field Laboratory, Hefei Institutes of Physical Science (Hips), Chinese Academy of Sciences, Hefei, Anhui, P. R. China.
Wenchu LinHigh Magnetic Field Laboratory, Hefei Institutes of Physical Science (Hips), Chinese Academy of Sciences, Hefei, Anhui, P. R. China.
Chinese Academy of Sciences · CNHigh Magnetic Field Laboratory · CNHefei Institutes of Physical Science · CNUniversity of Cape Coast · GHUniversity of Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alternative splicing (AS) is a common and pivotal process for eukaryotic gene expression regulation, which enables a precursor RNA to produce multiple transcript variants with diverse cellular functions. Aberrant AS represents a hallmark of cancer, engaged in all stages of tumorigenesis from initiation to metastasis. Accumulating pieces of evidence have revealed the involvement of non-coding RNAs (ncRNAs) in regulating AS in human cancers. In this review, we overview the underlying mechanisms of non-coding RNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) modulated AS at diverse levels in human cancers, and summarize their regulatory functions in tumorigenesis.

Indexed as

MicroRNAsNeoplasmsRNA, Long NoncodingAlternative SplicingCell Transformation, NeoplasticHumansRNA, CircularMicroRNAsRNA, CircularRNA, Long NoncodingAlternative splicingcancer progressioncircRNAlncRNAmiRNAsplicing factor

Identifiers

PMID35427215
PMCPMC9037454
OpenAlexW4226143149

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.