Evidence map›Paper›PMID 35427191›Full record

Trial reportNeurorehabilitation and neural repair2022

Early, Intensive, Lower Extremity Rehabilitation Shows Preliminary Efficacy After Perinatal Stroke: Results of a Pilot Randomized Controlled Trial.

Caitlin Hurd, Donna Livingstone, Kelly Brunton, Allison Smith, Monica Gorassini, Man-Joe Watt, John Andersen, Adam Kirton, Jaynie F Yang

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurorehabilitation and neural repair, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01773369 (Intensive Motor Training After Perinatal Stroke to Enhance Walking), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01773369 nacompletednot on this map

Intensive Motor Training After Perinatal Stroke to Enhance Walking

TypeinterventionalSponsorUniversity of AlbertaRan2012 to 2020Enrolled33ConditionsPerinatal StrokeArmsEarly leg training, Delayed leg training, Parent leg training
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Caitlin HurdDepartment of Physical Therapy, 3158University of Alberta, Edmonton, AB, Canada.
Donna LivingstoneDepartment of Physical Therapy, 3158University of Alberta, Edmonton, AB, Canada.
Kelly BruntonDepartment of Physical Therapy, 3158University of Alberta, Edmonton, AB, Canada.
Allison SmithDepartment of Physical Therapy, 3158University of Alberta, Edmonton, AB, Canada.
Monica GorassiniDepartment of Biomedical Engineering, 3158University of Alberta, Edmonton, AB, Canada.
Man-Joe WattDepartment of Physical Therapy, 3158University of Alberta, Edmonton, AB, Canada.
John AndersenDepartment of Physical Therapy, 3158University of Alberta, Edmonton, AB, Canada.ORCID 0000-0001-7138-3414
Adam KirtonDepartment of Physical Therapy, 3158University of Alberta, Edmonton, AB, Canada.
Jaynie F YangDepartment of Physical Therapy, 3158University of Alberta, Edmonton, AB, Canada.ORCID 0000-0002-7507-8924
University of Alberta · CA

Funding

CIHR MOP 126107
6 · The paper itself

Abstract

backgroundPerinatal stroke injures motor regions of the brain, compromising movement for life. Early, intensive, active interventions for the upper extremity are efficacious, but interventions for the lower extremity remain understudied.

objectiveTo determine the feasibility and potential efficacy of ELEVATE-Engaging the Lower Extremity Via Active Therapy Early-on gross motor function.

methodsWe conducted a single-blind, two-arm, randomized controlled trial (RCT), with the Immediate Group receiving the intervention while the Delay Group served as a 3-month waitlist control. A separate cohort living beyond commuting distance was trained by their parents with guidance from physical therapists. Participants were 8 months to 3 years old, with MRI-confirmed perinatal ischemic stroke and early signs of hemiparesis. The intervention was play-based, focused on weight-bearing, balance and walking for 1 hour/day, 4 days/week for 12 weeks. The primary outcome was the Gross Motor Function Measure-66 (GMFM-66). Secondary outcomes included steps and gait analyses. Final follow-up occurred at age 4.

resultsThirty-four children participated (25 RCT, 9 Parent-trained). The improvement in GMFM-66 over 12 weeks was greater for the Immediate than the Delay Group in the RCT (average change 3.4 units higher) and greater in younger children. Average step counts reached 1370-3750 steps/session in the last week of training for all children. Parent-trained children also improved but with greater variability.

conclusionsEarly, activity-intensive lower extremity therapy for young children with perinatal stroke is feasible and improves gross motor function in the short term. Longer term improvement may require additional bouts of intervention. CLINICAL

trial registrationThis study was registered at ClinicalTrials.gov (NCT01773369).

Indexed as

StrokeStroke RehabilitationChildChild, PreschoolHumansLower ExtremityParesisPilot ProjectsSingle-Blind MethodTreatment OutcomeUpper Extremitycerebral palsyearly interventionexerciseintensive trainingmotor skill trainingneuroplasticity

Identifiers

PMID35427191
PMCPMC9127938
OpenAlexW4223910148

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.