ArticleScience advances2022
Theory of defect-mediated morphogenesis.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- The Interplay of Curvature, Geometry, and Topology Shapes Tissue Organisation in Epithelial Shells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Boundary geometry controls a topological defect transition that determines lumen nucleation in embryonic development.Nature materials · 2026Article
- Light-Driven Topological Relaxation and Dynamic Scaling in Photoresponsive Polymer Films.ACS photonics · 2026Article
- Topological control of spontaneous failure in active nematic solids.Nature materials · 2026Article
- Harmonic fields and the mechanical response of a cellular monolayer to ablation.Journal of mathematical biology · 2026Article
- Topological signatures of collective dynamics and turbulent-like energy cascades in apolar active granular matter.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Shaping 3D minimal model tissues with mechanical constraints to orchestrate muscle differentiation.Communications biology · 2025Article
- Capturing nematic order on tissue surfaces of arbitrary geometry.Nature communications · 2025Article
- Topology controls flow patterns in active double emulsions.Nature communications · 2025Article
- Energetic scaling behavior of patterned epithelium.Journal of biomechanics · 2024Article
- Agent-based modeling of stress anisotropy driven nematic ordering in growing biofilms.Soft matter · 2024Article
- Machine learning topological defects in confluent tissues.Biophysical reports · 2024Article
- Biomechanical Modeling of Cell Chirality and Symmetry Breaking of Biological Systems.Mechanobiology in medicine · 2024Article
- Self-assembled active actomyosin gels spontaneously curve and wrinkle similar to biological cells and tissues.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Hexanematic crossover in epithelial monolayers depends on cell adhesion and cell density.Nature communications · 2023Article
- Article
- Patterning of morphogenetic anisotropy fields.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Topological defect-mediated morphodynamics of active-active interfaces.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growing experimental evidence indicates that topological defects could serve as organizing centers in the morphogenesis of tissues. Here, we provide a quantitative explanation for this phenomenon, rooted in the buckling theory of deformable active polar liquid crystals. Using a combination of linear stability analysis and computational fluid dynamics, we demonstrate that active layers, such as confined cell monolayers, are unstable to the formation of protrusions in the presence of disclinations. The instability originates from an interplay between the focusing of the elastic forces, mediated by defects, and the renormalization of the system's surface tension by the active flow. The posttransitional regime is also characterized by several complex morphodynamical processes, such as oscillatory deformations, droplet nucleation, and active turbulence. Our findings offer an explanation of recent observations on tissue morphogenesis and shed light on the dynamics of active surfaces in general.
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