Evidence map›Paper›PMID 35427157›Full record

ArticleScience advances2022

Cln5 represents a new type of cysteine-based

Anna V Luebben, Daniel Bender, Stefan Becker, Lisa M Crowther, Ilka Erven, Kay Hofmann, Johannes Söding, Henry Klemp, Cristina Bellotti, Andreas Stäuble and 7 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
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  9. Article
  10. An altered transcriptome underliesFrontiers in genetics · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Anna V LuebbenInstitute of Inorganic Chemistry, University of Göttingen, Tammannstrasse 4, 37077 Göttingen, Germany.ORCID 0000-0003-2867-9468
Daniel BenderDepartment of Pediatric Neurology, University Children's Hospital Zürich, University of Zurich, Steinwiesstrasse 75, 8032 Zürich, Switzerland.ORCID 0000-0002-2975-4186
Stefan BeckerDepartment of NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Fassberg 11, 37077 Göttingen, Germany.
Lisa M CrowtherDepartment of Pediatric Neurology, University Children's Hospital Zürich, University of Zurich, Steinwiesstrasse 75, 8032 Zürich, Switzerland.
Ilka ErvenInstitute for Genetics, University of Cologne, Zülpicher Str.47a, 50674 Cologne, Germany.ORCID 0000-0002-1095-6861
Kay HofmannInstitute for Genetics, University of Cologne, Zülpicher Str.47a, 50674 Cologne, Germany.ORCID 0000-0002-2289-9083
Johannes SödingQuantitative Biology and Bioinformatics and Department of Molecular Biology, Max-Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.ORCID 0000-0001-9642-8244
Henry KlempDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Neurology, University of Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, Germany.ORCID 0000-0002-3147-3017
Cristina BellottiDepartment of Pediatric Neurology, University Children's Hospital Zürich, University of Zurich, Steinwiesstrasse 75, 8032 Zürich, Switzerland.ORCID 0000-0002-3999-2807
Andreas StäubleDepartment of Pediatric Neurology, University Children's Hospital Zürich, University of Zurich, Steinwiesstrasse 75, 8032 Zürich, Switzerland.ORCID 0000-0001-9691-1690
Tian QiuDepartment of Chemistry, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-7168-0715
Rahul S KathayatDepartment of Chemistry, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-9159-2413
Bryan C DickinsonDepartment of Chemistry, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-9616-1911
Jutta GärtnerDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Neurology, University of Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, Germany.
George M SheldrickInstitute of Inorganic Chemistry, University of Göttingen, Tammannstrasse 4, 37077 Göttingen, Germany.
Ralph KrätznerDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Neurology, University of Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, Germany.
Robert SteinfeldDepartment of Pediatric Neurology, University Children's Hospital Zürich, University of Zurich, Steinwiesstrasse 75, 8032 Zürich, Switzerland.ORCID 0000-0003-0956-6601
University Children's Hospital Zurich · CHUniversity of Göttingen · DEUniversity of Chicago · USMax Planck Institute for Biophysical Chemistry · DEUniversity of Cologne · DE

Funding

Rapid selection approaches to understand and reprogram proteins and peptidesR35GM119840 · NIGMS · UNIVERSITY OF CHICAGO · PI Bryan Dickinson · 2016 to 2026
$4.8M
NIGMS NIH HHS R35 GM119840
6 · The paper itself

Abstract

Genetic

Indexed as

CysteineNeuronal Ceroid-LipofuscinosesChildHumansLysosomal Membrane ProteinsMembrane ProteinsCLN5 protein, humanCysteineLysosomal Membrane ProteinsMembrane Proteins

Identifiers

PMID35427157
PMCPMC9012467
OpenAlexW4224096847

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.