ArticleAging cell2022
How does maternal age affect genomic stability in the offspring?
Article in Aging cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Autonomous follicle quality control mechanisms: innate immune signaling capabilities of granulosa cells.Reproduction (Cambridge, England) · 2025Review
- Article
- Downregulation of transposable elements extends lifespan in Caenorhabditis elegans.Nature communications · 2023Article
- Epigenetics, ovarian cell plasticity, and platelet-rich plasma: Mechanistic theories.Reproduction & fertility · 2022Article
- The Effect of Maternal Age on the Incidence of Major Malformations and Operations in Children with Down Syndrome.Medeniyet medical journal · 2022Article
- How does maternal age affect genomic stability in the offspring?Aging cell · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In high-income countries, women tend to give birth at increasingly advanced ages. Despite its physiological, developmental, and medical consequences, why this tendency significantly affects genetic stability of the offspring remains largely unresolved. Accumulating evidence indicates that the higher the age of the mother at fertilization, the more intense the activity of transposable elements causing insertional mutations in functional DNA stretches in her oocyte involved in zygote formation.
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Registered trials
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