Evidence map›Paper›PMID 35426918›Full record

ArticleInteractive cardiovascular and thoracic surgery2022

Comparative analysis of the hydrogen sulphide pathway in internal thoracic artery and radial artery.

Yoonjin Kang, Jun Sung Kim, Huixing Cui, Myoung-Jin Jang, Yin Hua Zhang, Ho Young Hwang

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Interactive cardiovascular and thoracic surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yoonjin KangDepartment of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul, Republic of Korea.
Jun Sung KimDepartment of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
Huixing CuiDepartment of Physiology, College of Medicine, Seoul National University, Seoul, Republic of Korea.
Myoung-Jin JangMedical Research Collaborating Center, Seoul National University Hospital, Seoul National College of Medicine, Seoul, Republic of Korea.
Yin Hua ZhangDepartment of Physiology, College of Medicine, Seoul National University, Seoul, Republic of Korea.
Ho Young HwangDepartment of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul, Republic of Korea.ORCID 0000-0002-8935-8118
Seoul National University Hospital · KRSeoul National University · KRSeoul National University Bundang Hospital · KR

Funding

Seoul National University Hospital 0420200450
6 · The paper itself

Abstract

objectivesThe molecular basis supporting the superiority of the left internal thoracic artery (LITA) as a bypass conduit is limited. This study was conducted to compare the expression and localization of hydrogen sulphide synthesizing enzymes in LITA and radial artery (RA).

methodsNineteen patients who underwent coronary artery bypass grafting using LITA and RA were enrolled. The remnant LITA and RA were collected to measure the expression levels of 3 hydrogen sulphide-producing enzymes: cystathionine β-synthase, cystathionine γ-lyase and 3-mercaptopyruvate sulphurtransferase using quantitative real-time polymerase chain reaction. Expression levels of these enzymes in the LITA and RA were compared in each subject. The expression and localization patterns of the enzymes were also analysed by immunohistochemistry.

resultsThe mRNA expression of the cystathionine β-synthase was greater in the LITA than in the RA (P = 0.033), whereas the expression levels of the other 2 enzymes did not significantly differ between the 2 arteries. The immunohistochemistry analysis demonstrated greater expression of the cystathionine β-synthase in the LITA than in the RA (P = 0.006). This protein was present in both tunica intima and tunica media of the LITA, although it was present only in the tunica media of the RA. Localization patterns of the other 2 enzymes were not different between LITA and RA.

conclusionsExpression levels of the mRNA and protein of cystathionine β-synthase were significantly greater in LITA than in the RA. These findings might be a factor that affects the superior patency rate of LITA.

Indexed as

Hydrogen SulfideMammary ArteriesCystathionine beta-SynthaseHumansRadial ArteryRNA, MessengerTreatment OutcomeCystathionine beta-SynthaseHydrogen SulfideRNA, MessengerCoronary artery bypass graftingHydrogen sulphideInternal thoracic arteryRadial artery

Identifiers

PMID35426918
PMCPMC9631973
OpenAlexW4223965635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.