Evidence map›Paper›PMID 35426810›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2022

[Agkistrodon halys venom antitumor component-I inhibits vasculogenic mimicry in triple-negative breast cancer cells

Y Ge, L Lu, S Tian, Y Xiao, S Xie, Q Wang, H Zhi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Y GeDepartment of Pathology, Wannan Medical College, Wuhu 241002, China.
L LuDepartment of Pathology, Wannan Medical College, Wuhu 241002, China.
S TianDepartment of Pathology, Wannan Medical College, Wuhu 241002, China.
Y XiaoDepartment of Pathology, Wannan Medical College, Wuhu 241002, China.
S XieDepartment of Pathology, Wannan Medical College, Wuhu 241002, China.
Q WangDepartment of Pathology, Wannan Medical College, Wuhu 241002, China.
H ZhiDepartment of Pathology, Wannan Medical College, Wuhu 241002, China.
Wannan Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the inhibitory effect of agkistrodon halys venom antitumor component-I (AHVAC-I) on vasculogenic mimicry (VM) formation in triple-negative breast cancer MDA-MB-231 cells and explore its possible mechanism.

methodsCCK8 assay was used to determine the optimal concentration of AHVAC-I for cell treatment based on its halfinhibitory concentration (IC

resultsCompared with the control treatment with culture medium, treatment with 5, 10 and 20 μg/mL AHVAC-I significantly reduced vasomimetic ability of MDA-MB-231 cells in a dose-dependent manner (

conclusionAHVAC-I inhibits VM formation in triplenegative breast cancer cells

Indexed as

AgkistrodonTriple Negative Breast NeoplasmsAnimalsAntineoplastic AgentsCell Line, TumorHumansMatrix Metalloproteinase 2Neovascularization, PathologicVenomsAntineoplastic AgentsMatrix Metalloproteinase 2MMP2 protein, humanVenomsagkistrodon halys venom antitumor component-Imatrix metalloproteinase-2triple-negative breast cancervasculogenic mimicry

Identifiers

PMID35426810
PMCPMC9010989
OpenAlexW4223933024

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.