Evidence map›Paper›PMID 35426807›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2022

[Whole-transcriptome sequencing analysis of placental differential miRNA expression profile in Down syndrome].

J He, J Tang, H Su, C Shen, S Luo, H Wang, Y Qian, M Lü

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

J HeDepartment of Medical Genetics and Prenatal Diagnosis, Kunming Maternal and Child Health Care Hospital, Kunming 650031, China.
J TangDepartment of Medical Genetics and Prenatal Diagnosis, Kunming Maternal and Child Health Care Hospital, Kunming 650031, China.
H SuGenetic Counseling Clinic, Kunming Maternal and Child Health Care Hospital, Kunming 650031, China.
C ShenDepartment of Obstetrics, Kunming Maternal and Child Health Care Hospital, Kunming 650031, China.
S LuoDepartment of Medical Genetics and Prenatal Diagnosis, Kunming Maternal and Child Health Care Hospital, Kunming 650031, China.
H WangDepartment of Pathology, Kunming Maternal and Child Health Care Hospital, Kunming 650031, China.
Y QianDepartment of Medical Genetics and Prenatal Diagnosis, Kunming Maternal and Child Health Care Hospital, Kunming 650031, China.
M LüDepartment of Medical Genetics and Prenatal Diagnosis, Kunming Maternal and Child Health Care Hospital, Kunming 650031, China.
Yunnan Maternal and Child Health · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo identify new biomarkers and molecular pathogenesis of Down syndrome (DS) by analyzing differentially expressed miRNAs in the placentas and their biological pathways.

methodsWhole transcriptome sequencing was used to identify the differentially expressed miRNAs in DS (

resultsWe identified a total of 82 differentially expressed miRNAs in the placental tissues of DS, including 29 up-regulated miRNAs (fold change ≥2,

conclusionThe differentially expressed miRNAs may play important roles in placental damage and pregnancy pathology in DS and provide clues for the prevention and treatment of mental retardation-related diseases.

Indexed as

Down SyndromeMicroRNAsCytoskeletal ProteinsExome SequencingFemaleGene Expression ProfilingHumansNerve Tissue ProteinsPhosphatidylinositol 3-KinasesPlacentaPregnancyTranscription FactorsTranscriptomeAUTS2 protein, humanBTBD3 protein, humanCytoskeletal ProteinsMicroRNAsNerve Tissue ProteinsPhosphatidylinositol 3-KinasesTranscription FactorsDown syndromemicroRNAplacentatranscriptome sequencing

Identifiers

PMID35426807
PMCPMC9010987
OpenAlexW4223890654

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.