Evidence map›Paper›PMID 35426803›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2022

[CD36 gene deletion reduces muscle insulin sensitivity in mice by up-regulating PTP1B expression].

L Chen, H Zeng, H Qin, X Ruan, P Yang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

L ChenChongqing Key Laboratory of Lipid and Glucose Metabolism, Center for Lipid Research, Chongqing Medical University, Chongqing 400016, China.
H ZengChongqing Key Laboratory of Lipid and Glucose Metabolism, Center for Lipid Research, Chongqing Medical University, Chongqing 400016, China.
H QinChongqing Key Laboratory of Lipid and Glucose Metabolism, Center for Lipid Research, Chongqing Medical University, Chongqing 400016, China.
X RuanChongqing Key Laboratory of Lipid and Glucose Metabolism, Center for Lipid Research, Chongqing Medical University, Chongqing 400016, China.
P YangChongqing Key Laboratory of Lipid and Glucose Metabolism, Center for Lipid Research, Chongqing Medical University, Chongqing 400016, China.
Chongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effect CD36 deficiency on muscle insulin signaling in mice fed a normal-fat diet and explore the possible mechanism.

methodsWild-type (WT) mice and systemic CD36 knockout (CD36

resultsCD36

conclusionCD36 is essential for maintaining muscle insulin sensitivity under physiological conditions, and CD36 gene deletion in mice causes impaired insulin sensitivity by up-regulating muscle PTP1B expression, which results in detyrosine phosphorylation of IR and IRS1.

Indexed as

Gene DeletionInsulin ResistanceMembrane Cofactor ProteinProtein Tyrosine Phosphatase, Non-Receptor Type 1AnimalsHistonesInsulinInsulin Receptor Substrate ProteinsMiceMice, KnockoutMusclesPhosphoric Monoester HydrolasesProto-Oncogene Proteins c-aktReceptor, InsulinRNA, MessengerTyrosineHistonesInsulinInsulin Receptor Substrate ProteinsMcp protein, mouseMembrane Cofactor ProteinPhosphoric Monoester HydrolasesProtein Tyrosine Phosphatase, Non-Receptor Type 1Proto-Oncogene Proteins c-aktPtpn1 protein, mouseReceptor, InsulinRNA, MessengerTyrosineCD36insulin sensitivitymusclePTP1B

Identifiers

PMID35426803
PMCPMC9010982
OpenAlexW4223920464

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.