Evidence map›Paper›PMID 35426585›Full record

ReviewOral and maxillofacial surgery2023

The genetic factors contributing to the risk of cleft lip-cleft palate and their clinical utility.

Saeedeh Askarian, Masoumeh Gholami, Ghazaleh Khalili-Tanha, Negin Chaeichi Tehrani, Mona Joudi, Majid Khazaei, Gordon A Ferns, Seyed Mahdi Hassanian, Amir Avan, Marjan Joodi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Oral and maxillofacial surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. A Phenotypic Paradigm for Cerebral Palsy Genetics.medRxiv : the preprint server for health sciences · 2026
    Article
  5. Association between single nucleotide polymorphisms in vitamin D related and parathyroid hormone genes with nonsyndromic oral cleft.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Saeedeh Askarian *Department of Medical Biotechnology, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Masoumeh Gholami *Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
Ghazaleh Khalili-TanhaMetabolic syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Negin Chaeichi TehraniMetabolic syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mona JoudiCancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Majid KhazaeiMetabolic syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Gordon A FernsDivision of Medical Education, Brighton & Sussex Medical School, Falmer, Brighton, BN1 9PH, Sussex, UK.
Seyed Mahdi HassanianMetabolic syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Amir AvanMetabolic syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. avana@mums.ac.ir.ORCID http://orcid.org/0000-0001-9561-2306
Marjan JoodiEndoscopic and Minimally Invasive Surgery Research Center, Sarvar Children's Hospital, Mashhad, Iran. avana@mums.ac.ir.
Mashhad University of Medical Sciences · IRArak University of Medical Sciences · IRBrighton and Sussex Medical School · GBTorbat Heydarieh University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cleft lip and cleft palate (CL/P) are among the most common congenital malformations in neonates and have syndromic or nonsyndromic forms. Nonsyndromic forms of malformation are being reported to be associated with chromosomal DNA modification by teratogenic exposure and to complex genetic contributions of multiple genes. Syndromic forms are shown to be related to chromosomal aberrations or monogenic diseases. There is a growing body of data illustrating the association of several genes with risk of developing this malformation, including genetic defects in T-box transcription factor-22 (TBX22), interferon regulatory factor-6 (IRF6), and poliovirus receptor-like-1 (PVRL1), responsible for X-linked cleft palate, cleft lip/palate-ectodermal dysplasia syndrome, and Van der Woude and popliteal pterygium syndromes, respectively. Genetic variants in MTR, PCYT1A, ASS1, SLC 25A13, GSTM1, GSTT1, SUMO1 BHMT1, and BHMT2 are being reported to be linked with CL/P risk. The etiology of nonsyndromic CLP is still remained to be unknown, although mutations in candidate genes have been found. Here, we provide an overview about the potential variants to be associated with CL/P for identification of the relative risk of CLP with respect to the basis of genetic background and environmental factors (e.g., dietary factors, alcohol use).

Indexed as

Cleft LipCleft PalateSyndactylyFingersHumansInfant, NewbornInterferon Regulatory FactorsMutationInterferon Regulatory FactorsIRF6 protein, humanCleft lipCleft palateNonsyndromicSyndromic

Identifiers

PMID35426585
OpenAlexW4223906516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.