Evidence map›Paper›PMID 35426492›Full record

Trial reportPsychopharmacology2022

The effects of nalmefene on the impulsive and reflective system in alcohol use disorder: A resting-state fMRI study.

Nadja Grundinger, Sarah Gerhardt, Damian Karl, Karl Mann, Falk Kiefer, Sabine Vollstädt-Klein

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02372318 (Nalmefene Challenge to Modulate Neural Reactivity to Alcohol-related and Emotional Cues in Non-treatment Seeking Alcohol Dependent Participants), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02372318 early_phase1terminatednot on this map

Nalmefene Challenge to Modulate Neural Reactivity to Alcohol-related and Emotional Cues in Non-treatment Seeking Alcohol Dependent Participants

TypeinterventionalSponsorCentral Institute of Mental Health, MannheimRan2015 to 2016Enrolled23ConditionsAlcoholismArmsNalmefene, Placebo
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nadja GrundingerDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, PO Box 12 21 20, 68072, Mannheim, Germany.
Sarah GerhardtDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, PO Box 12 21 20, 68072, Mannheim, Germany.
Damian KarlDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, PO Box 12 21 20, 68072, Mannheim, Germany.
Karl MannDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, PO Box 12 21 20, 68072, Mannheim, Germany.
Falk KieferDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, PO Box 12 21 20, 68072, Mannheim, Germany.
Sabine Vollstädt-KleinDepartment of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, PO Box 12 21 20, 68072, Mannheim, Germany. s.vollstaedt-klein@zi-mannheim.de.ORCID http://orcid.org/0000-0002-6210-672X
Heidelberg University · DEUniversity of Mannheim · DE

Funding

Deutsche Forschungsgemeinschaft 324164820Deutsche Forschungsgemeinschaft 402170461Deutsche Forschungsgemeinschaft 421888313Deutsche Forschungsgemeinschaft 437718741
6 · The paper itself

Abstract

rationaleCentral aspects of alcohol use disorder (AUD) are the irresistible desire for alcohol and impaired control over its intake. According to the triadic neurocognitive model of addiction, this arises from aberrant functioning of different neural and cognitive systems: an impulsive system, a reflective system, and the abnormal dynamics between both systems based on an insular-dependent system.

objectivesIn this study, we examined the effects of a single dose of nalmefene on resting-state functional connectivity (rsFC) patterns within and between these addiction-related neural systems in AUD.

methodsNon-treatment seeking participants with AUD (N = 17; 19-66 years, 6 female) took part in a randomized, placebo-controlled, double-blind, crossover study and received either a single dose of 18 mg nalmefene or a placebo. Using seed-based correlation analyses on resting-state functional magnetic resonance imaging data, we examined the effects of nalmefene on key nodes related to the (1) impulsive system; (2) reflective system; (3) salience network; and (4) default mode network.

resultsUnder nalmefene, participants showed reduced rsFC between components of the impulsive system (Nucleus accumbens-putamen/pallidum/insula). Reduced rsFC was found between elements of the reflective system and impulsive system (orbitofrontal cortex-insula/putamen/pallidum), salience network (orbitofrontal cortex-insula/inferior frontal gyrus), and default mode network (lateral prefrontal cortex-precuneus/cuneus). Components of the salience network showed both increased (anterior cingulate cortex) and decreased (insular cortex) rsFC to elements of the reflective system.

conclusionA single dose of nalmefene impacts rsFC and alters the interaction between key nodes of addiction-related neural systems in non-treatment seeking participants with AUD. Nalmefene may normalize rsFC patterns by weakening the impulsive system while strengthening the reflective system.

trial registrationclinicaltrials.gov: NCT02372318.

Indexed as

AlcoholismMagnetic Resonance ImagingBrain MappingCross-Over StudiesFemaleHumansNaltrexonenalmefeneNaltrexoneAlcohol use disorderImpulsive systemNalmefenePharmacotherapyReduced drinkingReflective systemResting-state functional connectivitySalience network

Identifiers

PMID35426492
PMCPMC9293828
OpenAlexW4223925113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.