ArticleJournal of cachexia, sarcopenia and muscle2022
Clinical implications of low estimated protein intake in patients with heart failure.
Article in Journal of cachexia, sarcopenia and muscle, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Exercise, Nutrition and GLP-1 Medicines to Improve Body Weight and Muscle Function in Heart Failure with Preserved Ejection Fraction.Current heart failure reports · 2026Review
- Achieving Protein Requirements Through Oral Feeding in Children with Congenital Heart Disease: A Narrative Review.Children (Basel, Switzerland) · 2026Review
- The obesity paradox in super-elderly patients with heart failure: a retrospective cohort study.Heart and vessels · 2026Article
- Improving nutrition in pediatric heart failure.JHLT open · 2025Review
- Association between geriatric nutritional risk index and risk of heart failure: a cross-sectional study.BMC cardiovascular disorders · 2025Article
- State of the Art in Measuring Frailty in Patients With Heart Failure: from Diagnosis to Advanced Heart Failure.Current heart failure reports · 2025Review
- Large Variations in Phenylalanine Concentrations Associate Adverse Cardiac Remodelling in Adult Patients With Phenylketonuria-A Long-Term CMR Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- Malnutrition-related cardiomyopathy in a pediatric patient with autism spectrum disorder.JPGN reports · 2025Article
- Clinical Importance of Protein Intake in Hospitalized Elderly Patients With Heart Failure.Circulation reports · 2025Article
- Associations between in-hospital daily protein intake and adverse clinical outcomes in older patients with heart failure.ESC heart failure · 2024Article
- A Narrative Review of the Diagnosis and Treatment of Sarcopenia and Malnutrition in Patients with Heart Failure.Nutrients · 2024Review
- Oral nutritional supplements in older outpatients with heart failure: rationale and design of the ALIMENT-HF trial.ESC heart failure · 2024Article
- Frailty and heart failure: State-of-the-art review.Journal of cachexia, sarcopenia and muscle · 2023Review
- A more accurate method to estimate muscle mass: A new estimation equation.Journal of cachexia, sarcopenia and muscle · 2023Article
- Microbial metabolites in chronic heart failure and its common comorbidities.EMBO molecular medicine · 2023Article
- Article
- Sarcopenia and Frailty in Heart Failure: Is There a Biomarker Signature?Current heart failure reports · 2022Review
- Heart Failure and Pancreas Exocrine Insufficiency: Pathophysiological Mechanisms and Clinical Point of View.Journal of clinical medicine · 2022Review
- Clinical implications of low estimated protein intake in patients with heart failure.Journal of cachexia, sarcopenia and muscle · 2022Article
Corrections and comments
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Authors and funding
16 authors at 8 institutions in 6 countries.
Funding
Abstract
backgroundA higher protein intake has been associated with a higher muscle mass and lower mortality rates in the general population, but data about protein intake and survival in patients with heart failure (HF) are lacking.
methodsWe studied the prevalence, predictors, and clinical outcome of estimated protein intake in 2516 patients from the BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT-CHF) index cohort. Protein intake was calculated in spot urine samples using a validated formula [13.9 + 0.907 * body mass index (BMI) (kg/m
resultsWe included 2282 HF patients (mean age 68 ± 12 years and 27% female). Lower estimated protein intake in HF patients was associated with a lower BMI, but with more signs of congestion. Mortality rate in the lowest quartile was 32%, compared with 18% in the highest quartile (P < 0.001). In a multivariable model, lower estimated protein intake was associated with a higher risk of death compared with the highest quartile [hazard ratio (HR) 1.50; 95% confidence interval (CI) 1.03-2.18, P = 0.036 for the lowest quartile and HR 1.46; 95% CI 1.00-2.18, P = 0.049 for the second quartile].
conclusionsAn estimated lower protein intake was associated with a lower BMI, but signs of congestion were more prevalent. A lower estimated protein intake was independently associated with a higher mortality risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.