ArticlePlant biotechnology journal2022
Riboflavin integrates cellular energetics and cell cycle to regulate maize seed development.
Article in Plant biotechnology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 43 citations in OpenAlex.
- Atypical E2F transcription factors couple Polycomb Repressive Complex 2 to endosperm cell division and differentiation.Nature plants · 2026Article
- Riboflavin-primed seeds reduce arsenic stress inPeerJ · 2026Article
- Proteome Reprogramming and Acquired Stress Tolerance in Potato Cells Exposed to Acute or Stepwise Water Deficit.Plant, cell & environment · 2025Article
- Development of certain benzylidene coumarin derivatives as anti-prostate cancer agents targeting EGFR and PI3Kβ kinases.Journal of enzyme inhibition and medicinal chemistry · 2024Article
- Dynamic atlas of histone modifications and gene regulatory networks in endosperm of bread wheat.Nature communications · 2024Article
- The Influence of Barley Proteome on Hop Bitter Acid Yield during Brewing.Journal of agricultural and food chemistry · 2024Article
- Comparative transcriptome profiling reveals the mechanism of increasing lysine and tryptophan content through pyramidingBreeding science · 2024Article
- Mathematical kinetic modelling followed by in vitro and in vivo assays reveal the bifunctional rice GTPCHII/DHBPS enzymes and demonstrate the key roles of OsRibA proteins in the vitamin B2 pathway.BMC plant biology · 2024Article
- Effect of different harvest times and processing methods on the vitamin content of Leymus.Frontiers in nutrition · 2024Article
- Metabolomics and machine learning technique revealed that germination enhances the multi-nutritional properties of pigmented rice.Communications biology · 2023Article
- Riboflavin mediates m6A modification targeted by miR408, promoting early somatic embryogenesis in longan.Plant physiology · 2023Article
- Riboflavin integrates cellular energetics and cell cycle to regulate maize seed development.Plant biotechnology journal · 2022Article
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Authors and funding
14 authors at 3 institutions in 1 country.
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Abstract
Riboflavin is the precursor of essential cofactors for diverse metabolic processes. Unlike animals, plants can de novo produce riboflavin through an ancestrally conserved pathway, like bacteria and fungi. However, the mechanism by which riboflavin regulates seed development is poorly understood. Here, we report a novel maize (Zea mays L.) opaque mutant o18, which displays an increase in lysine accumulation, but impaired endosperm filling and embryo development. O18 encodes a rate-limiting bifunctional enzyme ZmRIBA1, targeted to plastid where to initiate riboflavin biosynthesis. Loss of function of O18 specifically disrupts respiratory complexes I and II, but also decreases SDH1 flavinylation, and in turn shifts the mitochondrial tricarboxylic acid (TCA) cycle to glycolysis. The deprivation of cellular energy leads to cell-cycle arrest at G1 and S phases in both mitosis and endoreduplication during endosperm development. The unexpected up-regulation of cell-cycle genes in o18 correlates with the increase of H3K4me3 levels, revealing a possible H3K4me-mediated epigenetic back-up mechanism for cell-cycle progression under unfavourable circumstances. Overexpression of O18 increases riboflavin production and confers osmotic tolerance. Altogether, our results substantiate a key role of riboflavin in coordinating cellular energy and cell cycle to modulate maize endosperm development.
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