Evidence map›Paper›PMID 35426178›Full record

ArticleJournal of veterinary internal medicine2022

Prevalence of clinical signs and factors impacting expression of myosin heavy chain myopathy in Quarter Horse-related breeds with the MYH1

Stephanie J Valberg, Abigail E Schultz, Carrie J Finno, Rebecca R Bellone, Shayne S Hughes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Myosin Heavy Chain Myopathy and Immune-Mediated Muscle Disorders.The Veterinary clinics of North America. Equine practice · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Stephanie J ValbergLarge Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.ORCID https://orcid.org/0000-0001-5978-7010
Abigail E SchultzLarge Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
Carrie J FinnoDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, California, USA.ORCID https://orcid.org/0000-0001-5924-0234
Rebecca R BelloneDepartment of Population Health and Reproduction, Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California Davis, Davis, California, USA.ORCID https://orcid.org/0000-0001-8838-7227
Shayne S HughesUniversity of California Davis, Davis, California, USA.
University of California, Davis · USMichigan State University · US

Funding

NCATS NIH HHS L40 TR001136
6 · The paper itself

Abstract

backgroundThe prevalence of clinical signs and factors triggering muscle atrophy and rhabdomyolysis associated with an MYH1 HYPOTHESIS/

objectivesDetermine the prevalence and potential triggers of atrophy and stiffness in horses homozygous reference (N/N), heterozygous (My/N), and homozygous (My/My) for the MYH1 ANIMALS: Two-hundred seventy-five N/N, 100 My/N, and 10 My/My QH.

methodsA retrospective case-control study using a closed-ended questionnaire completed by clients of the Veterinary Genetics Laboratory at the University of California, Davis. History of clinical signs, disease, vaccination and performance were analyzed by genotype using contingency testing.

resultsAtrophy occurred in proportionately more horses with MYH1 CONCLUSION AND CLINICAL IMPORTANCE: Approximately 20% of My/N QH develop rapid atrophy. Atrophy is more common (80%) in homozygous My/My QH and less likely to resolve. Inciting causes such as vaccination and infection are inapparent in over half of cases.

Indexed as

Horse DiseasesMuscular DiseasesAnimalsCase-Control StudiesHorsesHumansMuscular AtrophyMutationMyosin Heavy ChainsPrevalenceRetrospective StudiesMyosin Heavy Chainsatrophyequinemusclerhabdomyolysis

Identifiers

PMID35426178
PMCPMC9151494
OpenAlexW4223939060

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.