Evidence map›Paper›PMID 35426064›Full record

ArticleIn vitro cellular & developmental biology. Animal2022

MiR-149-5p promotes β-catenin-induced goat hair follicle stem cell differentiation.

Jian Wang, Xi Wu, Liuming Zhang, Qiang Wang, Jingwen Qu, Yanhu Wang, Dejun Ji, Yongjun Li

Abstract read
PubMed Publisher
In one paragraph

Article in In vitro cellular & developmental biology. Animal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Feasibility of repairing skin defects by VEGFJournal of cellular and molecular medicine · 2023
    Article
  8. miR-27a TargetingAnimals : an open access journal from MDPI · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jian Wang *College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, Jiangsu, China.
Xi Wu *College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, Jiangsu, China.
Liuming ZhangCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, Jiangsu, China.
Qiang WangCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, Jiangsu, China.
Jingwen QuCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, Jiangsu, China.
Yanhu WangCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, Jiangsu, China.
Dejun JiCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, Jiangsu, China.
Yongjun LiCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, Jiangsu, China. liyj@yzu.edu.cn.ORCID http://orcid.org/0000-0002-7913-8533
Yangzhou University · CN

Funding

Graduate Research and Innovation Projects of Yangzhou University XKYCX20_027National Natural Science Foundation of China 31572355Priority Academic Program Development of Jiangsu Higher Education Institutions 2014-134Priority Academic Program Development of Jiangsu Higher Education Institutions PAPD
6 · The paper itself

Abstract

The Yangtze River Delta white goat is a unique goat species that can produce superior-quality brush hair. The formation of superior-quality brush hair cannot occur without goat hair follicle stem cell differentiation. However, knowledge regarding the regulatory role of miR-149-5p in hair follicle stem cell differentiation is limited. Here, we found that miR-149-5p is widely expressed in the tissues of Yangtze River Delta white goats, but its expression in the skin tissue of superior-quality brush hair goats is high compared to normal- quality goats. The functional studies showed that miR-149-5p overexpression markedly facilitated hair follicle stem cell differentiation, whereas inhibiting miR-149-5p inhibited hair follicle stem cell differentiation. These results more clearly elucidate the regulatory role of miR-149-5p in hair follicle stem cell growth.

Indexed as

Hair FollicleMicroRNAsAnimalsbeta CateninCateninsCell DifferentiationGoatsbeta CateninCateninsMicroRNAsC-mycDifferentiationKrt6miR-149-5pβ-catenin

Identifiers

PMID35426064
OpenAlexW4223957244

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.