Evidence map›Paper›PMID 35425986›Full record

Trial reportPediatrics2022

An Intervention in Congruence for End-of-Life Treatment Preference: A Randomized Trial.

Justin N Baker, Sarah Friebert, Jennifer Needle, JiJi Jiang, Jichuan Wang, Maureen E Lyon

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02693665 (Building Evidence for Effective Palliative/End of Life Care for Teens With Cancer), which is not on this map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
6.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02693665 nacompletednot on this map

Building Evidence for Effective Palliative/End of Life Care for Teens With Cancer

TypeinterventionalSponsorMaureen LyonRan2016 to 2022Enrolled260ConditionsCancerArmsFAmily CEntered Advance Care Planning for Teens with Cancer
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 1 country.

Justin N BakerDivision of Quality of Life and Palliative Care, St. Jude Children's Research Hospital, Memphis, Tennessee.
Sarah FriebertHaslinger Family Pediatric Palliative Care Center.
Jennifer NeedleDepartment of Pediatrics and Center for Bioethics, University of Minnesota, Minneapolis, Minnesota.
JiJi JiangHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland.
Jichuan WangDivisions of Biostatistics and Study Methodology.
Maureen E LyonAdolescent and Young Adult Medicine.
Akron Children's Hospital · USChildren's National · USGeorge Washington University · USHenry M. Jackson Foundation · USSt. Jude Children's Research Hospital · USUniversity of Minnesota · US

Funding

Clinical and Translational Science Institute at Children's NationalUL1TR000075 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI GUAY-WOODFORD, LISA MARIE · 2012 to 2015
$13.7M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR031988 · NCRR · CHILDREN'S RESEARCH INSTITUTE · PI GUAY-WOODFORD, LISA MARIE · 2010 to 2011
$8.2M
Building Evidence for Effective Palliative/End of Life Care for Teens with CancerR01NR015458 · NINR · CHILDREN'S RESEARCH INSTITUTE · PI LYON, MAUREEN ELLEN · 2015 to 2019
$3.4M
NCATS NIH HHS UL1 TR000075NCRR NIH HHS UL1 RR031988NINR NIH HHS R01 NR015458
6 · The paper itself

Abstract

BACKGROUND AND

objectivesThere is a gap in family knowledge of their adolescents' end-of-life (EOL) treatment preferences. We tested the efficacy of Family Centered Advance Care Planning for Teens with Cancer (FACE-TC) pediatric advance care planning (to increase congruence in EOL treatment preferences.

methodsAdolescents with cancer/family dyads were randomized into a clinical trial from July 2016 to April 2019 at a 2:1 ratio: intervention (n = 83); control (n = 43) to either 3 weekly sessions of FACE-TC (Lyon Advance Care Planning Survey; Next Steps: Respecting Choices Interview; Five Wishes, advance directive) or treatment as usual (TAU). Statement of Treatment Preferences measured congruence.

resultsAdolescents' (n = 126) mean age was 16.9 years; 57% were female and 79% were White. FACE-TC dyads had greater overall agreement than TAU: high 34% vs 2%, moderate 52% vs 45%, low 14% vs 52%, and P < .0001. Significantly greater odds of congruence were found for FACE-TC dyads than TAU for 3 of 4 disease-specific scenarios: for example, "a long hospitalization with low chance of survival," 78% (57 of 73) vs 45% (19 of 42); odds ratio, 4.31 (95% confidence interval, 1.89-9.82). FACE-TC families were more likely to agree to stop some treatments. Intervention adolescents, 67% (48 of 73), wanted their families to do what is best at the time, whereas fewer TAU adolescents, 43% (18 of 42), gave families this leeway (P = .01).

conclusionsHigh-quality pediatric advance care planning enabled families to know their adolescents' EOL treatment preferences.

Indexed as

Advance Care PlanningNeoplasmsTerminal CareAdolescentAdvance DirectivesChildDeathFamilyFemaleHumansMale

Identifiers

PMID35425986
PMCPMC9648108
OpenAlexW4224108933

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.