ArticleCritical care explorations2022
Prognostic Accuracy of Presepsis and Intrasepsis Characteristics for Prediction of Cardiovascular Events After a Sepsis Hospitalization.
Article in Critical care explorations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Atrial fibrillation in critical illness: state of the art.Intensive care medicine · 2025Review
- Scoping review of the use of multimorbidity variables in cardiovascular disease risk prediction.BMC public health · 2025Article
- Predicting stroke risk after sepsis hospitalization with new-onset atrial fibrillation.Journal of hospital medicine · 2024Article
- Development and validation of a machine learning model using electronic health records to predict trauma- and stressor-related psychiatric disorders after hospitalization with sepsis.Translational psychiatry · 2023Article
- Cardiovascular Disease After COVID-19: A Call to Action.JACC. Advances · 2023Article
- Prevalent diabetes and long-term cardiovascular outcomes in adult sepsis survivors: a population-based cohort study.Critical care (London, England) · 2023Article
- Predicting Cardiovascular Events after Sepsis with Death as a Competing Risk.Annals of the American Thoracic Society · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
objectivesSepsis survivors face increased risk for cardiovascular complications; however, the contribution of intrasepsis events to cardiovascular risk profiles is unclear.
settingKaiser Permanente Northern California (KPNC) and Intermountain Healthcare (IH) integrated healthcare delivery systems. SUBJECTS: Sepsis survivors (2011-2017 [KPNC] and 2018-2020 [IH]) greater than or equal to 40 years old without prior cardiovascular disease.
designData across KPNC and IH were harmonized and grouped into presepsis (demographics, atherosclerotic cardiovascular disease scores, comorbidities) or intrasepsis factors (e.g., laboratory values, vital signs, organ support, infection source) with random split for training/internal validation datasets (75%/25%) within KPNC and IH. Models were bidirectionally, externally validated between healthcare systems.
interventionsNone. MEASUREMENTS AND MAIN
resultsChanges to predictive accuracy (
conclusionsAcross two large healthcare systems, intrasepsis factors improved postsepsis cardiovascular risk prediction as compared with presepsis cardiovascular risk profiles. Further exploration of sepsis factors that contribute to postsepsis cardiovascular events is warranted for improved mechanistic and predictive models.
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Registered trials
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