Evidence map›Paper›PMID 35425867›Full record

ArticleHealth science reports2022

Triple apheresis platelet concentrate quality after pneumatic tube system, conveyor box, and courier transport: An observational study.

Lena Reichert, Stefan Wallner, Ralph Burkhardt, Robert Offner, Norbert Ahrens, Viola Hähnel

Open access · goldAbstract read
In one paragraph

Article in Health science reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lena ReichertInstitute for Clinical Chemistry and Laboratory Medicine University Hospital Regensburg Regensburg Germany.
Stefan WallnerInstitute for Clinical Chemistry and Laboratory Medicine University Hospital Regensburg Regensburg Germany.ORCID 0000-0002-3365-9579
Ralph BurkhardtInstitute for Clinical Chemistry and Laboratory Medicine University Hospital Regensburg Regensburg Germany.ORCID 0000-0003-1924-1202
Robert OffnerInstitute for Clinical Chemistry and Laboratory Medicine University Hospital Regensburg Regensburg Germany.ORCID 0000-0003-0160-8248
Norbert AhrensInstitute for Clinical Chemistry and Laboratory Medicine University Hospital Regensburg Regensburg Germany.ORCID 0000-0002-4680-2688
Viola HähnelInstitute for Clinical Chemistry and Laboratory Medicine University Hospital Regensburg Regensburg Germany.ORCID 0000-0003-4115-8405
University Hospital Regensburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Platelets are prone to activation from handling; they are therefore transported as gently as possible, most commonly by courier. Speedier methods like pneumatic tube system (PTS) transport could improve patient care but may subject platelets to mechanical stress. To test the impact of mechanical stress caused by transport, we compared a PTS with a conveyor box and courier transport on apheresis platelet function. Methods: Fourteen apheresis platelet concentrate triple donations were analyzed by light transmission aggregometry (LTA), rotational thrombelastometry (ROTEM), and flow cytometry before and after indoor transport over 800 m by PTS, conveyor, and courier, respectively, while recording shocks and vibrations with a high-frequency acceleration data logger. Shock index scores were calculated as shock intensity (g-force) times frequency. Results: The shock index was 81 for courier, 6279 for conveyor, and 9075 for PTS. Flow cytometry revealed no significant difference in platelet surface expression of CD62p before (16%) and after transport via courier (15%), conveyor (14%), or PTS (16%). LTA with adenosine phosphate and thrombin receptor-activating peptide-6 resulted in comparable platelet aggregation for courier, conveyor, and PTS. ROTEM assays showed no relevant differences in coagulation time, clot formation time, and maximum clot firmness between transport modes. Conclusion: Though the mechanical challenge was smallest with courier transport, there were no significant differences in platelet activation or aggregation between the three transport modes. These data contradict restrictions on the use of PTSs for platelet concentrate transport.

Indexed as

apheresis platelet concentratesconveyor systemplatelet functionpneumatic tube system

Identifiers

PMID35425867
PMCPMC8989271
OpenAlexW4223933474

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.