Evidence map›Paper›PMID 35425787›Full record

ArticleFrontiers in nutrition2022

Causal Association Between Tea Consumption and Kidney Function: A Mendelian Randomization Study.

Yangchang Zhang, Yang Xiong, Shisi Shen, Jialu Yang, Wei Wang, Tingting Wu, Li Chen, Qiuhua Yu, Hangjia Zuo, Xu Wang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
8.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
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  9. [Causal relationship between autoimmune diseases and aplastic anemia: A Mendelian randomization study].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
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  18. Causal relationships between dietary antioxidant vitamin intake and atopic dermatitis: A two-sample Mendelian randomization study.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Yangchang ZhangSchool of Public Health and Management, Chongqing Medical University, Chongqing, China.
Yang XiongThe West China Hospital, Sichuan University, Chengdu, China.
Shisi ShenThe First School of Clinical Medicine, Chongqing Medical University, Chongqing, China.
Jialu YangSchool of Public Health and Management, Chongqing Medical University, Chongqing, China.
Wei WangSchool of Public Health and Management, Chongqing Medical University, Chongqing, China.
Tingting WuChongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing, China.
Li ChenSchool of Public Health & Institute of Child and Adolescent Health, Peking University, Beijing, China.
Qiuhua YuDepartment of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Hangjia ZuoThe First School of Clinical Medicine, Chongqing Medical University, Chongqing, China.
Xu WangSchool of Public Health and Management, Chongqing Medical University, Chongqing, China.
Xun LeiSchool of Public Health and Management, Chongqing Medical University, Chongqing, China.
Chongqing Medical University · CNChongqing Public Health Medical Center · CNChongqing University of Education · CNPeking Union Medical College Hospital · CNPeking University · CNWest China Hospital of Sichuan University · CN

Funding

Medical Research Council MC_PC_17228Medical Research Council MC_QA137853
6 · The paper itself

Abstract

Background: Causal research concerning the consumption of tea and the risk of chronic kidney disease (CKD) is limited. This study identified the potential causal effects of tea intake on CKD, the estimated glomerular filtration rate (eGFR), and albuminuria. Methods: Genome-wide association studies (GWASs) from UK Biobank were able to identify single-nucleotide polymorphisms (SNPs) associated with an extra cup of tea each day. The summary statistics for the kidney function from the CKDGen consortium include 11,765 participants (12,385 cases of CKD) and 54,116 participants for the urinary albumin-to-creatinine ratio who were mostly of European descent. A two-sample Mendelian randomization (MR) analysis was performed to test the relationship between the selected SNPs and the risk of CKD. Results: A total of 2,672 SNPs associated with tea consumption ( Conclusion: From the perspective of genes, causal relationships exist between daily extra cup of tea and the reduced risk of CKD and albuminuria and increased eGFR.

Indexed as

albuminuriachronic kidney disease (CKD)Mendelian randomizationSNPstea consumption

Identifiers

PMID35425787
PMCPMC9002236
OpenAlexW4220951998

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.