ArticleFrontiers in medicine2022
Metagenomic Next-Generation Sequencing to Investigate Infectious Endophthalmitis of Brucella: A Case Report.
Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Endophthalmitis caused by Shinella species: the first case report.Journal of ophthalmic inflammation and infection · 2026Article
- A case of uveitis and retinal vasculitis induced by varicella-zoster virus: vitrectomy treatment and literature review.BMC ophthalmology · 2026Review
- Article
- Endogenous endophthalmitis secondary to neisseria meningitidis: a case report.BMC ophthalmology · 2026Article
- Metagenomic Next-Generation Sequencing in Brucellar Spondylitis with Discordant Serologic Findings in a Non-Endemic Region: A Case Report and Literature Review.Infection and drug resistance · 2026Article
- Metagenomic Next-Generation Sequencing Unmasks Atypical Rabies - Guangxi Zhuang Autonomous Region, China, 2024.China CDC weekly · 2025Article
- Review
- Diagnostic value of metagenomic next-generation sequencing in atypical brucellosis: a case report.Frontiers in medicine · 2025Article
- Case Report: Next-generation metagenomic sequencing in the diagnosis ofFrontiers in medicine · 2025Article
- Meta-genomic next-generation sequencing in the diagnosis of brucellosis: Five cases from a non-endemic area.Future microbiology · 2024Article
- Fulminant endogenous endophthalmitis caused byClinical case reports · 2023Article
- Comparative evaluation of 16S rRNA metagenomic sequencing in the diagnosis and understanding of bacterial endophthalmitis.BMJ open ophthalmology · 2023Article
- Role of Recent PCR Tests for Infectious Ocular Diseases: From Laboratory-Based Studies to the Clinic.International journal of molecular sciences · 2023Review
- Ocular Lesions in Brucella Infection: A Review of the Literature.Infection and drug resistance · 2022Review
- Nanopore techniques as a potent tool in the diagnosis and treatment of endophthalmitis: a literature review.International journal of ophthalmology · 2022Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Brucellosis is a systemic disease that exists prevalently in clinical manifestations. The symptoms present in organs such as the eyes (in ocular brucellosis) can lead to misdiagnosis or even failure to diagnose. Metagenomic Next-Generation Sequencing (mNGS), a high-throughput sequencing approach, could be applied for the detection of microorganisms. Case Presentation: A 57-year-old female with acute right-eye vision loss, treated with clindamycin and dexamethasone sodium phosphate for 1.5 months, was difficult to diagnose using regular methods. mNGS was utilized for the aqueous fluid from the patient, and Brucella melitensis was identified. The inflammation was treated with 3 months of antibiotherapy. However, even with specific medicine and surgery, the vision remained poor because severe ocular conditions last for a long time. Conclusion: It suggests that brucella should still be a probable pathogen in endophthalmitis despite its low incidence in non-epidemic areas. Moreover, mNGS can achieve early diagnosis and timely treatment for difficult-to-diagnose ocular infections.
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