Evidence map›Paper›PMID 35425699›Full record

ArticleFrontiers in oncology2022

Tumor Suppressor Par-4 Regulates Complement Factor C3 and Obesity.

Nathalia Araujo, James Sledziona, Sunil K Noothi, Ravshan Burikhanov, Nikhil Hebbar, Saptadwipa Ganguly, Tripti Shrestha-Bhattarai, Beibei Zhu, Wendy S Katz, Yi Zhang and 14 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Loss ofOncotarget · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 5 institutions in 2 countries.

Nathalia AraujoDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, United States.
James SledzionaDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, United States.
Sunil K NoothiDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY, United States.
Ravshan BurikhanovDepartment of Radiation Medicine, University of Kentucky, Lexington, KY, United States.
Nikhil HebbarDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, United States.
Saptadwipa GangulyDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, United States.
Tripti Shrestha-BhattaraiDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Beibei ZhuDivision of Internal Medicine, University of Kentucky, Lexington, KY, United States.
Wendy S KatzBarnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, KY, United States.
Yi ZhangDepartment of Computer Science, University of Kentucky, Lexington, KY, United States.
Barry S TaylorDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Jinze LiuDepartment of Computer Science, University of Kentucky, Lexington, KY, United States.
Li ChenDivision of Internal Medicine, University of Kentucky, Lexington, KY, United States.
Heidi L WeissDivision of Internal Medicine, University of Kentucky, Lexington, KY, United States.
Daheng HeDepartment of Statistics, University of Kentucky, Lexington, KY, United States.
Chi WangMarkey Cancer Center, University of Kentucky, Lexington, KY, United States.
Andrew J MorrisDivision of Internal Medicine, University of Kentucky, Lexington, KY, United States.
Lisa A CassisBarnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, KY, United States.
Mariana Nikolova-KarakashianMarkey Cancer Center, University of Kentucky, Lexington, KY, United States.
Prabhakar R NagareddyDivision of Cardiac Surgery, The Ohio State University, Columbus, OH, United States.
Olle MelanderDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
B Mark EversMarkey Cancer Center, University of Kentucky, Lexington, KY, United States.
Philip A KernDivision of Internal Medicine, University of Kentucky, Lexington, KY, United States.
Vivek M RangnekarDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, United States.
University of Kentucky · USMarkey Cancer Center · USMemorial Sloan Kettering Cancer Center · USLund University · SEThe Ohio State University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI KATHLEEN L. O'CONNOR · 2013 to 2026
$38.3M
TRAINING GRANT IN MOLECULAR MECHANISMS OF TOXICITY.T32ES007266 · NIEHS · UNIVERSITY OF KENTUCKY · PI LIU, XIAOQI, MELLON, ISABEL W · 1990 to 2020
$3.7M
Interdisciplinary Research Training in Cancer BiologyT32CA165990 · NCI · UNIVERSITY OF KENTUCKY · PI Bernard Mark Evers, KATHLEEN L. O'CONNOR · 2013 to 2026
$3.2M
Training Program For Cancer Prevention and ControlT32CA229114 · NCI · OHIO STATE UNIVERSITY · PI Chyke Abadama Doubeni, Peter G. Shields · 2018 to 2026
$2.0M
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA177558NCI NIH HHS T32 CA165990NCI NIH HHS T32 CA229114NIEHS NIH HHS T32 ES007266
6 · The paper itself

Abstract

Prostate apoptosis response-4 (Par-4) is a tumor suppressor that induces apoptosis in cancer cells. However, the physiological function of Par-4 remains unknown. Here we show that conventional Par-4 knockout (Par-4

Indexed as

acylation stimulating proteinadipocyte tissue storageC3fat absorptionhypertrophic obesityPar-4

Identifiers

PMID35425699
PMCPMC9004617
OpenAlexW4221108819

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.