Evidence map›Paper›PMID 35425061›Full record

ReviewRSC advances2022

The pinene scaffold: its occurrence, chemistry, synthetic utility, and pharmacological importance.

Rogers J Nyamwihura, Ifedayo Victor Ogungbe

Abstract readReview
In one paragraph

Review in RSC advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Herb and Flowers ofMolecules (Basel, Switzerland) · 2023
    Article
  13. TiRSC advances · 2023
    Article
  14. Article
  15. Characterization ofFrontiers in plant science · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Rogers J NyamwihuraDepartment of Chemistry, Jackson State University 1400 John R. Lynch Street Jackson MS 39217 USA Ifedayo.v.ogungbe@jsums.edu +1-601-979-3719.
Ifedayo Victor OgungbeDepartment of Chemistry, Jackson State University 1400 John R. Lynch Street Jackson MS 39217 USA Ifedayo.v.ogungbe@jsums.edu +1-601-979-3719.ORCID https://orcid.org/0000-0002-8048-5137

Funding

Lead Optimization and Mechanisms of Action of Dual-Acting Antitrypanosomal AgentsSC1GM140990 · NIGMS · JACKSON STATE UNIVERSITY · PI OGUNGBE, IFEDAYO VICTOR · 2021 to 2023
$1.1M
Hit to Lead Optimization of Non-Peptidic Inhibitors of Alphaviral Cysteine ProteaseR21AI159740 · NIAID · JACKSON STATE UNIVERSITY · PI WHITTAKER, JOSEPH A · 2021 to 2022
$620k
NIAID NIH HHS R21 AI159740NIGMS NIH HHS SC1 GM140990
6 · The paper itself

Abstract

Plant-based secondary metabolites have been a major source of drug discovery and inspiration for new generations of drugs. Plants offer a wide variety of compound classes, including alkaloids, terpenes, flavonoids, and glycosides, with different molecular architectures (fused bridgehead, bi- and polycyclic, spirocyclic, polycyclic, and acyclic). The diversity, abundance, and accessibility of plant metabolites make plants an attractive source of human and animal medicine. Even though the pinene scaffold is abundant in nature and has historical use in traditional medicine, pinene and pinene-derived compounds have not been comprehensively studied for medicinal applications. This review provides insight into the utility of the pinene scaffold as a crucial building block of important natural and synthetic products and as a chiral reagent in the asymmetric synthesis of important compounds.

Identifiers

PMID35425061
PMCPMC9003397

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.