ArticleRSC advances2022
Investigation on photopolymerization of PEGDA to fabricate high-aspect-ratio microneedles.
Article in RSC advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Hydrogel microneedles functioning in pathological surroundings: where soft materials overcome hard scars.Materials today. Bio · 2026Review
- Low-Shrinkage 3D-Printed Polymeric Microneedle Arrays with Electroless Silver Coating for Enhanced Thermal and Mechanical Performance in Dermatological Applications.Materials (Basel, Switzerland) · 2026Article
- Bioinspired maskless structural colour patterning via tunable nanoparticle segregation.Nature communications · 2026Article
- Machine learning-driven design of engineered cilia enables hybrid operations in acoustic microrobots.Nature communications · 2026Article
- Strategic advances in Vat Photopolymerization for 3D printing of calcium phosphate-based bone scaffolds: A review.Bioactive materials · 2025Review
- Unravelling the role of microneedles in drug delivery: Principle, perspectives, and practices.Drug delivery and translational research · 2024Review
- Microneedle-mediated treatment for superficial tumors by combining multiple strategies.Drug delivery and translational research · 2023Review
- Advancing bovineFrontiers in bioengineering and biotechnology · 2023Article
- Fabrication and characterization of photosensitive non-isocyanate polyurethane acrylate resin for 3D printing of customized biocompatible orthopedic surgical guides.International journal of bioprinting · 2023Article
- 3D Printability Assessment of Poly(octamethylene maleate (anhydride) citrate) and Poly(ethylene glycol) Diacrylate Copolymers for Biomedical Applications.ACS applied polymer materials · 2022Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microneedles (MNs) are micron-sized needles that can penetrate the stratum corneum, enabling the non-invasive and painless administration of drugs and vaccines. In this work, fabrication conditions for high-aspect-ratio MNs by the photopolymerization of polyethylene glycol diacrylate (PEGDA) were investigated. Ultraviolet (UV) light was used to crosslink photocurable prepolymers in specific areas defined by a photomask. The aspect ratio of solidified MNs is too small to penetrate the stratum corneum if the degree of polymerization is insufficient. However, if the degree of polymerization is too high, a film is formed between the MNs by solidification of an undesired area owing to the scattering effect, reducing needle height. The influence of prepolymer molecular weight and the degree of UV absorption by the photoinitiator (PI) were studied to optimize the conditions for obtaining high-aspect-ratio MNs. Additionally, the effect of spacing ratio on high-aspect-ratio MNs without film formation has been discussed. A penetration test was conducted with porcine skin to analyze the effect of mechanical properties of MN. This study could guide the fabrication of MNs by the photopolymerization of biocompatible polymers with a photomask.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.