Evidence map›Paper›PMID 35424591›Full record

ArticleRSC advances2022

Three-component assembly of stabilized fluorescent isoindoles.

Vladimir A Maslivetc, James J La Clair, Alexander Kornienko

Abstract read
In one paragraph

Article in RSC advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vladimir A MaslivetcDepartment of Chemistry and Biochemistry, Texas State University San Marcos Texas 78666 USA a_k76@txstate.edu.ORCID https://orcid.org/0000-0002-6290-0691
James J La ClairXenobe Research Institute P.O. Box 3052 San Diego CA 92163-1052 USA i@xenobe.org.ORCID https://orcid.org/0000-0001-6500-4107
Alexander KornienkoDepartment of Chemistry and Biochemistry, Texas State University San Marcos Texas 78666 USA a_k76@txstate.edu.ORCID https://orcid.org/0000-0003-2041-7367

Funding

Acid-Sensitive Glioblastoma Prodrugs Derived from Ophiobolin AR15CA227680 · NCI · TEXAS STATE UNIVERSITY · PI KORNIENKO, ALEXANDER · 2019 to 2019
$462k
Tandem Discovery of Drug Leads and Targets via Paal-Knorr reactionR21GM131717 · NIGMS · TEXAS STATE UNIVERSITY · PI KORNIENKO, ALEXANDER, LA CLAIR, JAMES J · 2019 to 2020
$374k
NCI NIH HHS R15 CA227680NIGMS NIH HHS R21 GM131717
6 · The paper itself

Abstract

The tandem addition of an amine and a thiol to an aromatic dialdehyde engages a selective three-component assembly of a fluorescent isoindole. While an attractive approach for diversity-based fluorophore discovery, isoindoles are typically unstable and present considerable challenges for their practical utility. We found that introduction of electron-withdrawing substituents into the dialdehyde component affords stable isoindole products in one step with acceptable yields and high purity.

Identifiers

PMID35424591
PMCPMC8982182

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.