ArticleRSC advances2021
Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine.
Article in RSC advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Protopeptide backbone affects assembly in aqueous solutions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Reproducible Ala-Gly oligomerization catalyzed by the natural Borate colemanite in prebiotic conditions.Scientific reports · 2025Article
- Evolution of complex chemical mixtures reveals combinatorial compression and population synchronicity.Nature chemistry · 2025Article
- Catalytic peptide/hemin complex from ester-amide exchange reaction mediated by deep eutectic solvents.RSC advances · 2025Article
- From Catalysis of Evolution to Evolution of Catalysis.Accounts of chemical research · 2024Article
- A Prebiotic Precursor to Life's Phosphate Transfer System with an ATP Analog and Histidyl Peptide Organocatalysts.Journal of the American Chemical Society · 2024Article
- C2-addition patterns emerging from acetylene and nickel sulfide in simulated prebiotic hydrothermal conditions.Communications chemistry · 2023Article
- A New Approach in Prebiotic Chemistry Studies: Proline Sorption Triggered by Mineral Surfaces Analysed Using XPS.Life (Basel, Switzerland) · 2023Article
- How to build a protoribosome: structural insights from the first protoribosome constructs that have proven to be catalytically active.RNA (New York, N.Y.) · 2023Article
- Formation, stabilization and fate of acetaldehyde and higher aldehydes in an autonomously changing prebiotic system emerging from acetylene.Communications chemistry · 2023Article
- Recent progress in primitive polyester synthesis and membraneless microdroplet assembly.Biophysics and physicobiology · 2023Article
- Thioesters provide a plausible prebiotic path to proto-peptides.Nature communications · 2022Article
- Differential Oligomerization of Alpha versus Beta Amino Acids and Hydroxy Acids in Abiotic Proto-Peptide Synthesis Reactions.Life (Basel, Switzerland) · 2022Article
- Connecting primitive phase separation to biotechnology, synthetic biology, and engineering.Journal of biosciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biochemistry exhibits an intense dependence on metals. Here we show that during dry-down reactions, zinc and a few other transition metals increase the yield of long histidine-containing depsipeptides, which contain both ester and amide linkages. Our results suggest that interactions of proto-peptides with metal ions influenced early chemical evolution.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.